268 THE JOURNAL OF PHARMACOLOGY. 



of the palate, are unable for the time to take oil. It seems to have all 

 the virtues of the oil without its nourishing and fattening qualities. 



I have found this fortified oil more easily taken than others. It 

 is less repulsive to the taste and smell, and in many cases patients soon 

 learn to like its taste as well as its eiifects. It is more easily digested 

 and much less liable to be followed by eructations. This increased 

 digestibility is no doubt due to the soothing influences of the iodine on 

 the stomach-walls. It is more prompt in its systematic effects in 

 building up the tissues. Its alterative effects are more prompt and 

 more pronounced. The prescription reads as follows: 



Olei Morrhuae lodo-phosphoratum Oi. 



S. One tablespoonful at night, only on retiring, pre- 

 ferably followed by a taste of lemon. 



For a period of perhaps seven years I have constantly been pre- 

 scribing it, using it in a thousand or more cases, and I have had but two 

 or three instances in which patients insisted that they could not take it. 

 I have not observed a single case in which it had a bad effect, and in 

 every case I believe I noticed an advantageous effect markedly beyond 

 that which I formerly observed in similar cases when using the plain 

 oil in equal (juantity. I have named it lodo-Phosphori'sed Cod-Liver 

 Oil, and usually write my prescriptions as here noted, rarely ordering it 

 to be taken more than once a day and then at bed-time. When necessary 

 to use it oftener I prescribe it at meal-time in addition, but I do this 

 rarely. Occasionally I have the patient take a little whisky with the 

 oil, but almost invariably advise that a piece of lemon be used after 

 taking the oil. 



I believe this matter of prescribing the oil at night, the last thing at 

 night just before slipping into bed and taking the lemon thereafter, to 

 be a very important one to the patient, making its administration more 

 pleasant and its digestion more rapid. 



This preparation of oleum morrhuse iodo-phosphoratum is a per- 

 fectly stable preparation made agreeable by the addition of aromatics, 

 containing 95 per cent, of pure Lofoten cod-liver oil, each ounce con- 

 taining one-sixth of a grain of pure free iodine and one-fiftieth of a 

 grain of pure free phosphorus. It will keep indefinitely if stored in a 

 cool place and tightly corked, but, like all cod-liver oils, if kept too long, 

 for a few years, for instance, or exposed to the light, the fatty acids 

 become oxidized, in other words, hydroxylation occurs and the oil 

 then becomes unpleasant to the stomach. 



No cod-liver oil, however, can be expected to keep well without 

 hydroxylation for a much greater period than a year after its prepar- 

 ation, and this preparation of oleum morrhuae iodo-phosphoratum must 



