272 THE JOURNAL OF PHARMACOLOGY. 



On the day after the patient's death the post-mortem made by 

 Privy-Councillor Dr. Orth revealed the following- facts in reg'ard to 

 this interesting point : 



Marked edematous swelling of the lower extremities ; large decub- 

 ital necrosis of both feet and above the achilles tendons, and the same 

 over the sacrum, especially on the left side. Bullae of the epidermis and 

 sanguinous suffusion on the posterior and inner side of the right thigh. 

 Above the sacrum on the right side, and under unchanged skin, is an 

 immense pus cavity stretching towards the thigh, and filled with a mass 

 of bloody and purulent foul-smelling matter. Surface of the gluteal 

 muscles colored dark grey and infiltrated with pus. On the left side 

 in the corresponding location is another phlegmon, more intermus- 

 cularly located. Here also the muscles are changed into a soft, dirty 

 grey mass. In the middle of the thighs upon both sides edema only ; no 

 suppuration. A large cavity filled with pus and containing, like the 

 previous one, large shreds of fatty tissue, surrounds the entire end of 

 the rectum and the anus. Inspection of the anterior surface of the 

 body shows that on the right thigh the necrosis of the skin and the phleg- 

 mons extend to the inner side of the limb. The knee joint contains 

 bloody looking pus. Over the internal condyle is an abscess of the 

 soft parts. The inguinal lymphatic glands are enlarged. On the 

 left side also there is suppurative inflammation of the knee joint with 

 phlegmons of the surrounding tissues. 



The urinary bladder is firmly contracted, and contains only a very 

 small quantity of very slightly purulent fluid. The cavities between 

 the folds of the contracted bladder are vividly reddened. Between 

 the muscular tabeculae are various small diverticulum-like dilations. 

 Severe inflammatory changes are not present. The entrance of the 

 urethra shows nothing noticeably abnormal; but above the folliculus 

 seminalis there are on both sides openings of false passages. The one 

 on the left side is somewhat the wider, but leads to a passage only i^ cm. 

 (3-5 inch) long; the one on the right is 3I cm. (i| inches) long, and 

 ends in a blind sack behind the swelling of the ureter. The pars nuda 

 and the posterior portion of the pars cavernosa of the urethra sliow a 

 brownish discoloration; then follows grey mucous membrane; the an- 

 teiYr portion is greyish-brown again. A longitudinal section shows 

 no'hing unusual. 



Section of the prostate shows suppurative foci on the right side, and 

 the prostatic veins contain loose thrombi of mixed appearance. The 

 nu-.cosa of the left ureter, the pelvis, and the chalices of the lei*: kidney 

 are indeed here and ther a little more vascular than usual, and the 

 pelvic membrane has a few minute hemorrhages. But there are abso- 



