peach-colored urine, sometimes quite bloody, which upon cooling 

 contained large and small clots of reddish and yellowish jelly-like 

 material. These fibrinous clots were sometimes passed through the 

 urethra and occasioned some pain. In the centrifugal precipitate a 

 of number filaria-like organisms were found, but as none could be 

 observed in the peripheral circulation during the day or at night, 

 the patient was put on tonics and boric-acid bladder irrigations until 

 the end of June, when urotropin, 1 gram three times a day, was 

 given and the douches changed to bichloride of mercury 1-10,000, 

 while morphine was administered hypodermatically for the pain. 



At 9 p. m. July 23 filaria, resembling those occurring in the 

 urine, were found in the blood from a finger. The patient was kept 

 in a bed, the foot of which was elevated, and received just enough 

 food, without fats, and lic^uid to sustain life, and a very Aveak 

 solution of adrenalin chloride was injected into the bladder and 

 allowed to remain. 



From August 1 to 15 the adrenalin was given by mouth, in doses 

 of 10 to 15 drops of a. 1-1,000 solution every four hours during the 

 daytime, 40 to 50 drops per day. On August 15 this treatment was 

 stopped. At this, time some swelling of the right thigh developed 

 but subsided after a few days. The patient remained in the 

 elevated bed until the middle of October. 



On August 29 methylene blue, 0.12 gram every four hours, was 

 given by mouth. This was stopped on September 4 on account of 

 the occurrence of violent emesis. 



At the suggestion of Dr. W.. E. Musgrave we attempted to 

 "sensitize" the adult parasites by the administration of quinine 

 followed by the exposure of the body of the patient, through the 

 lumbar region, to the X-rays. She was given 80 to 90 grains of 

 quinine sulphate during forty- eight hours, followed by X-ray 

 exposures of five minutes, with the tube 18 inches away. Quinine 

 having been administered daily, these exposures were performed 

 from 2 to 3 p. m. on September 8, 10, 11, 12, 14, 16, 17, 18, and again, 

 after cinchonizing as before, at 9 p. m. on September 28 and 30.^ 



1 Unfortunately we are unable to state the exact hardness of the X-ray 

 bulbs. In order to obtain a clear radiograph of the l)ones of the pelvis with 

 this apparatus an exposure of fifteen minutes with the bulb at a distance of 

 5 inches from the skin surface is necessary. Filarial embryos in a thin layer 

 of blood, collected after cinchonizing, exposed to the rays for five minutes 

 with the bulb 16 inches away are not killed, but they squirm about in a very 

 excited manner. 



