47 



amoebas in the lesions and there was very active leucocytic infiltra- 

 tion with marked coincident karyorhexis, a very uncommon picture 

 for araoebiasis. 



When amoebge are found in exudates rich in bacteria they show 

 evidence within their bodies of a very active phagocytosis. 



CONCLUSIONS. 



I. Intestinal amoebiasis is a peculiar ulcerative condition of the 

 intestine caused by Am(vha coU (Losch), usually confined to the 

 large intestine, though occasionally (7 in 200 cases) the ileum is 

 affected and more often (14 in 200 cases) the appendix is involved. 



II. In the majority of cases the condition affects the entire bowel 

 (159 in 200 cases), though it may be limited to one or more por- 

 tions, most commonly the caecum and ascending colon (23 in 200 

 cases). 



III. The ulcers show a tendency to be undermined, due to the 

 lack of resistance on the part of the submucous layer of the bowel. 



lY. The organisms may enter the blood vessels very early in 

 the disease and may be transported to the submucosa without lesions 

 of the muscularis mucosa. 



Y. The disease is a subacute chronic inflammatory process, as 

 shown by the character of the exudate and infiltration, by the early 

 formation of granulation tissue, and by the absence of leucocytic 

 infiltration. 



YI. Complete healing may be accomplished, or a condition of 

 chronic atrophic enteritis or chronic catarrh may persist, which is 

 known as sprue or psilosis. 



