THE PATHOLOGY OF INTESTINAL AMOEBIASIS. 



By Paul G. Woolley, M. D., Director Hcriim Lnboratory, and \V. E. 

 MUSGKAVK, M. D., Pathologist Biological Laboratory. 



In former papers, one of ns (Musgrave), Bnllelin So. IS, has 

 dealt with the subject of the cultivation and etiological significance 

 of amoebae. The following remarks will be limited to the pathol- 

 ogy of the intestinal amoebic disease : 



It may be well to state at the outset that we can see no valid 

 reason "for departing from the nomenclature of Losch. He 

 described a pathogenic amoeba and called it Amceba coli. Why 

 this term should be applied to a supposititious nonpathogenic 

 organism it is difficult to say. We shall in referring to the cause 

 of intestinal amoebiasis use the name introduced by Losch. 



Among the many articles in the literature of amoebiasis there 

 are l)ut few which arc of special value from the pathologic side. 

 Chief among these are those of Councilman and Lafleur (Johns 

 Ilopl-iiis Hospital Beports, 1891, it, 395), Harris {Amer. Jour. 

 Mrd.Sc, 189S, CXV, 384), Howard (Buck's Reference Handhoolc, 

 1000), and Eogers (Brit. Med. Jour., 1903, I, 1315). Taken 

 together, these works give a very c()m})leto picture of the disease as 

 we have seen it. 



Material. — This has ])een obtained from various sources, among 

 which have been the First Eeserve Hospital, Bilibid Prison, and the 

 Civil Hospital, all in ifanila. Other material has been obtained 

 from the service of Dr. Strong and the private practices of 

 Drs. ^IcDill and ^Musgrave, also of Manila. 



Methods. — Bits of tissue from autopsies were fixed in Zi'uker's 

 solution, in absolute alcohol, Flemming's solution, and Kaiserling, 

 and ultimately imbedded in paraffin. 



Sections from alcohol tissues were stained by Mallory's thionin 

 and oxalic metiiod, those from Flemming's solution in siifranin and 



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