Workshop, held at Sanibel Island, Fla., in February 1966. It was attended by 

 31 scientists, all of them cell biologists specialized either in immunology or in 

 developmental biology. Only three of the participants came from outside the 

 U.S.A. 



The book contains 23 papers, the majority of which are research reports. They 

 are grouped in four parts, the first of which is devoted to general problems of 

 differentiation and its genetic control (an introduction by Ebert, and papers by 

 Schneiderman on insects, by Papaconstantinou on the vertebrate lens, by Schimke 

 on the control of protein synthesis generally, and by Konigsberg on clonal 

 techniques as applied to problems of cytodifferentiation). Part two is entitled 

 "Differentiation of cells of lymphoreticular system" (6 papers, all dealing with 

 mammalian cells). Part three deals with "Embryonic development of form and 

 function of the lymphoreticular system" (5 papers, one dealing with frogs, two 

 with the chick, and two with mammals). Finally, part four discusses the "Pre- 

 and postnatal function of the lymphoreticular system" (7 papers, one dealing 

 with turtles, one with the opossum, and the remainder with other mammals). A 

 synthesis of the workshop is provided by the editors. All papers are followed by 

 group discussions. In them, participants often refer to work of other investigators, 

 but references to such work are unfortunately not provided. 



The book is well-produced and illustrated with numerous photographs and 

 graphs. There is a rather brief subject index, and no author index. 



43 PHENOTYPIC EXPRESSION 



Immunological, biochemical, and morphological 

 1966 



Edited by the Tissue Culture Ass., Inc. The Williams 6 Wilkins Cy. 

 (C. J. Dawe, Editor-in-Chief) Baltimore, Md. 



"In Vitro" vol. 2 Price: $ 9.50 



181 pp., 46 figs.. 35 tbs. 



Contributors: Bach (Madison, Wis.), Black (Bethesda, Md.), DeMars (Madison, Wis.), 

 Ephrussi (Cleveland, Ohio), Franks (Cambridge), Green (New York, N.Y.), Hiramoto (Mem- 

 phis, Tenn.), Hirschhorn (New York, N.Y.), Krooth (Ann Arbor, Mich.), Merchant (Ann Arbor, 

 Mich.), Nossal (Melbourne), Ohno (Duarte, Calif.) 



This volume contains the papers read at a four-day Symposium held in San 

 Francisco in May/June 1966. The Symposium was concerned mainly with the 

 phenotype of cultured cells at the cellular and molecular level. All contributors 

 except one were American scientists. The volume furthermore contains the 

 abstracts of the papers presented at the 17th Annual Meeting of the Tissue 

 Culture Association, as well as a committee report on the proposed usage of 

 animal tissue culture terms. 



Of the twelve main papers four deal with the growth and function of plasma 

 cells and lymphocytes after antigenic stimulation. Ephrussi then describes new 

 interspecific mammalian somatic cell hybrids obtained in vitro, while Ohno pre- 

 sents cytological and genetical evidence of somatic segregation in mammals, 

 birds, and fishes. Two papers review the biological events occurring after 

 infection of cells with DNA viruses, while two other papers deal with antigenic 

 heterogeneity in cell cultures, and with stability of cell antigens and their value 

 as genetic markers. Finally, two papers are concerned with the genetics of cells 



37 



