igi5] Edwin D. IVafkins 95 



munication. Suffice it to say that the results from the use of the sol. 

 in the treatment of gonorrhea have been most gratifying to those 

 who have used it. My colleagues here and in other places have 

 reported to me splendid success with it. Extending its use I tried 

 it on chancroids, tonsilHtis, ulcers of various kinds, and in one case 

 of amebic infection of the colon. This last case was reported in 

 the Journal of the American Medical Association, vol. Ix, pp. 1357 

 and 1358(1913). It has been found especially beneficial in chronic 

 gonorrheal Urethritis and in gonorrhea in women. 



Until recently I had no positive evidence that I had made a Com- 

 pound of silver, quinin and the acid. All attempts to obtain crystals 

 met with failure. Almost by accident a crystal was found in a conc. 

 sol. which had stood unmolested in a dark cabinet from October, 

 191 3, to December, 1914. On closer investigation two complex 

 crystals were found in the bottom of the flask containing the conc. 

 sol. which had stood 15 months. These were removed, carefully 

 washed and dried. They were very dense; their color was dark 

 yellow. One of them was used in demonstrating the presence of 

 silver, quinin and phosphoric acid; the other is now in safe keeping 

 for further investigation. 



The crystal was decomposed in heated strong nitric acid, and 

 the presence of silver demonstrated by precipitation with sodium 

 Chlorid and the character of the resulting precipitate. An ammo- 

 nium phosphomolybdate precipitate was then obtained. On addi- 

 tion of strong ammonia to the nitric acid sol. of the crystal, a heavy 

 yellow precipitate was thrown down, which was dissolved with 

 excess of ammonia when, in the top of the sol., there appeared a 

 flocculent white precipitate that proved to be quinin. One of my 

 associates went over the work with me, so that there could be no 

 mistake in it. A quantitative analysis of the crystal has not been 

 made. That will be done at an early opportunity. 



In place of silver I have made sol. of copper phosphate and zinc 

 phosphate with quinin, quinidin, cinchonin and cinchonidin. The 

 relative merits clinically of these sol. remains for future determina- 

 tion. No crystals of these Compounds, if they be such, have been 

 obtained. 



