1915] Jacob Rosenbio om 9^ 



doubted opium poisoning, as well as in the urine of morphinists, has 

 also strengthened the idea that the alkaloid is modified or rendered 

 undetectable in the System.^ However, Marquis^ after the injection 

 of morphine into the circulation of cats, recovered from the liver 

 30 percent of the injected amount; and Antheaume and Mouneyrat/" 

 in a case of morphine poisoning in an individual who had previously 

 used 62 grains daily (recently 30 grains daily), but who had taken 

 no morphine f or the preceding two weeks, f ound morphine in large 

 quantity in the liver. 



As morphine, through its phenolic hydroxid, combines with Sul- 

 fate to form a Compound similar in structure to the ethereal sulfate 

 normally contained in urine, the possibility of such a formation in 

 the body suggests itself. Eliasso w^^ and Stolnikow^^ have shown 

 that the proportion of ethereal sulfates is increased under treatment 

 with morphine.^^ The results of Rubsamen's^* experiments tend to 

 show that a certain percentage of injected morphine disappears in 

 the bodies of rats, and that this proportion is increased by habitua- 

 tion. The changes said to occur are effected by oxidation or by 

 "pairing." There has been considerable controversy^^ about these 

 experiments, however, and the matter is still unsettled. 



8 Cloetta : Virchow's Arch., 1866, xxxv, p. 369 ; Taylor : On Poisons, 3d ed., 

 pp. 556 and 559; Buchner: N. Rept. f. Pharm., 1867, xvi, p. 43; Landsberg: 

 Pflüger's Arch., 1880, xxiii, p. 413; Puschmann : Dissert, Göttingen, 1895; Wel- 

 mans: Pharm Ztg., 1898, xliii, p. 908; Stursberg: Arch. Int. de pharmacodyn., 

 1898, iv, p. 333; Bougault: Compt. rend. Acad. Sei., 1902, cxxxiv, p. 1361 ; 

 Gerard, Delearde et Ricquet: Jr. de pharm, et de chim., 1905, 6S, xxii, p. 49; 

 Stolnikow : Dissert., Lausanne, 1899 ; Marquis : Arh. a. d. pharm. Inst. 2. Dorpat, 

 1896, xiv, p. 118; Strzyzowski: Dissert, Lausanne, 1899. 



9 Marquis : Chem. Centralbl., 1897, i, p. 249. 



10 Antheaume and Mouneyrat: Compt. rend., 1897, cxxiv, p. I47S- 

 " Eliassow : Dissert, Königsberg, 1882. 



12 Stolnikow : Zeit. f. physiol. Chem., 1884, viii, p. 235. 



13 This might be due, however, to the constipating action of morphine. 



14 Rubsamen : Arch. f. e.vp. Path. u. Pharm., 1908, lix, p. 227 ; see also Faust, 

 ibid., 1900, xliv, p. 217. 



15 Marme : Deut. med. Woch., 1883, ix, p. 197 ; Polstorff : Berichte, 1880, xiii, 

 p. 86; 1886, xix, p. 176; Brookmann and Polstorff: ibid., 1880, xiii, p. 88, 

 Pelletier: Ann. de chim. et de phys., 1835, xvi, p. 50; Hesse: Liebig' s Ann., 1867, 

 cxli, p. 87 ; 1875, clxxvi, p. I95 ; 1883, ccxxii, p. 234 ; 1886, ccxxxiv, p. 253, ccxxxv, 

 p. 229; Vongerichten: ibid., 1896, ccxciv, p. 206; Lamal: Bull. Ac. r. de Med. de 

 Belg., 1888, 4S, ii, p. 639 ; Jr. de pharm, et de chim., 1904, xix, p. 61 ; Diedrich : 

 Diss., Göttingen, 1883 ; Donath : /. /. prakt. Chem., 1886, xxxiii, p. 559 ; Pflüger's 

 Arch., 1886, xxxviii, p. 528. 



