I9I5] 



Casimir Funk 



29 



3. In the third series (Table 3), where the inoculation period, 

 and the size of the tumor, were noted, the average result was simi- 

 lar to that in the previous experiment ( i ) ; but we see that the size 

 of the tumor had no effect, on the numerical values. 



4. In the f ourth series of experiments serum was always taken 

 from pairs of animals, to insure rehable results. (Table 4.) We 

 see, from the foregoing data, that nitrogen was very much higher, 

 and phosphorus, sulfur, chlorin and molecular depression slightly 

 higher, in normal serum. In the Rous sera, amino-nitrogen and 

 sugar were slightly higher. Two tumor sera (Nos. 14 and 18) gave 

 contradictory values. This may be due to the resistance of the body 

 to tumor growth. In these two animals the tumor was older than 

 in others but attained only a very small size, with a capsule separat- 

 ing it entirely from the rest of the muscle tissue. 



TABLE 5 



Data pertaining to serum analysed directly. 

 {Serum of rats with Jensen's sarcoma: values per 100 gm. of serum.) 



5. In the fifth experiment six rats with small tumors were bled 

 by cutting the throats; the blood volumes were combined. Five 

 normal rats were treated in the same way. (Table 5.) 



We see, also, chemical changes in the same direction for rats. 



This result will be checked by f urther study. 



324 West Ena Avenue, 

 New York City. 



