ipis] Frederic G. Goodridge and Max Kahn 125 



was less than 2 percent of the total sulfur. Considering it from 

 this point of view, 90.9 percent of normal cases gave a negative 

 Salomon and SaxI reaction. 



In the results for 59 urinary examinations of cases of Cancer 

 (Table 2), the colloidal-nitrogen percent was generally increased 

 to as high as 5.75 percent of the total nitrogen, the minimum being 

 3.4 percent. Fifty-eight of the 59 cases of Cancer gave a positive 

 Salomon and Saxl reaction. We are doubtful whether the case in 

 which it was negative (case 27) was one of true malignancy, the 

 diagnosis having been made clinically. 



Table 3 is the most interesting. Forty-seven cases of diseases 

 other than Cancer were studied. We obtained positive results with 

 the colloidal-nitrogen estimations in cases of myocarditis, diabetes 

 and Syphilis. The colloidal nitrogen is constantly increased in 

 amount in diabetics. Wallace,^* basing his conclusion on the find- 

 ings in only two cases, states that this increase is not constant and 

 that there is no relationship between the colloidal-nitrogen outptit 

 and the severity of the diabetes. Tuberculosis and the other diseases 

 gave negative results. On the other hand tuberculosis, hemophilia, 

 pernicious anemia, and atrophic cirrhosis of the liver, gave positive 

 Salomon and Saxl neutral-sulfur reactions, whereas the other dis- 

 eases reacted negatively. 



General conclusion. We conclude that positive results with 

 either the colloidal-nitrogen test or the neutral-sulfur test, alone, 

 are not indicative of Carcinoma. When performed conjointly on 

 urine of the same case, however, positive results with both methods 

 are strongly indicative of malignancy. 



Further work along these lines is desirable. 



BIBLIOGRAPHY 



1. Töpfer: Wiener klin. Woch., 1892, v, p. 49. 



2. BoNDZYNSKi and Gottlieb: Zentralb. f. d. med. Wiss., 1897, 



XXXV, p. 577. 



3. Salkowski: Berliner klin. Woch., 1910, xlvii, p. 1746. 



4. Hess and Saxl : Beitrag, z. Carcinomforsch., 1910, part IL 



5. Salkowski and Kojo: Berliner klin. Woch., 1910, xlvii, p. 2297. 



6. Kojo: Zeit. f. physiol. Chem., 191 1, Ixxiii, p. 416. 



7. Einhorn, Kahn and Rosenbloom : Arch. f. Verdauungsh nk., 



1911, xvii, p. 557. 



