The book contains the proceedings of a conference held late in 1962 at the 

 University of Minnesota. It had close to one hundred participants, 19 of which 

 came from countries other than the U.S.A. and Canada. The book consists of 

 36 papers with discussions, a general discussion, and a general summary. The 

 papers are grouped into five sections, entitled: I. Introduction (2 papers); 

 II. Anatomy and chemistry of the thymus (4 papers); III. The thymus and 

 bursa of Fabricius: Lymphocytopoiesis (12 papers); IV. The thymus and bursa 

 of Fabricius: the immune response (13 papers); V. The thymus in experimental 

 and clinical disease (5 papers). 



It is impossible to list all papers that are of possible interest to our readers. 

 Only a few will be specifically mentioned. The first is that by Talmage and 

 Claman: "Cell potential: its mutation and selection. A theory of differentiation 

 based on antibody production". In this paper a general model of cell differen- 

 tiation is presented which is based on the concepts of specific protein synthesis 

 and "asymmetric" cell division. Although the model is intended to apply to all 

 differentiative processes, it is discussed chiefly in relation to the thymus. 



The other papers to be mentioned specifically are those by Auerbach: 

 "Experimental analysis of mouse thymus and spleen morphogenesis" and by 

 Papermaster, Condie, Finstad, and Good: "Significance of the thymus in the 

 evolution of the lymphoid tissue and acquired immunity". 



The book is well illustrated, mainly with photographs. It is concluded by a 

 combined author-subject index. 



38. CYTOGENETICS OF CELLS IN CULTURE 



1964 



Editor: R. J. C. Harris Academic Press 



Symposia Int. Soc. Cell Biol., vol. 3 New York — London 



325 pp.. 147 figs., 42 tbs. Price: $ 13.— 



In this international symposium emphasis was laid on 1 ) new techniques to 

 detect patterns of DNA replication, to better understand cellular control 

 mechanisms, and to perform chromosome analyses with automated instrumen- 

 tation; 2) the effect of cell hybridization and of noxious substances such as 

 radiation, chemical agents, and viruses on chromosomal patterns, and 3) the 

 influence of altered chromosomal complement on the survival of cells in long- 

 term culture or after ionizing radiation treatment. 



Although some of the topics will be of peripheral interest to many embryol- 

 ogists, the implications of the papers of, for example, Barski and of Ephrussi 

 et al. on the hybridization of somatic cells in vitro, that of Frederic and Corin- 

 Frederic on chromosomal alterations of cells cultivated in the presence of 

 heterologous tissue extracts, that of J. H. Taylor on the regulation of DNA 

 replication and variegation-type position effects, and that of German on iden- 

 tification and characterization of human chromosomes by DNA replication 

 sequence, may interest those concerned with the mechanisms of cellular control. 



Contributors: Barski (VUlejuif), Cho (Boston, Mass.), Cohn (Madison, Wise), Conn- 

 Frederic (Liege), Ephrussi (Cleveland, Ohio), Ford (Harwell), Fraccaro (Pavia), Frederic 



(Liege), German (New York, N.Y.), Hayflick (Philadelphia, Penn.), Ho (Boston, Mass.), 

 Jacobs (Edinburgh), Kihlman (Uppsala), Levan (Lund), Lima-de-Faria (Lund). Lindsten 



(Stockholm), Makino (Sapporo), Moorhead (Philadelphia, Penn.), Nakanishi (Chiba), Nichols 



355 



