papers); 3) Organization and function of enzyme systems and subcellular units 

 (4 papers); 4) New antibiotics (1 paper); 5) Chemical approaches to im- 

 munology (2 papers); 6) Cellular, subcellular and molecular aspects of dif- 

 ferentiation (4 papers). 



It is particularly the last group of papers which is of interest to develop- 

 mental biologists. The following papers are included: "Morphogenesis of 

 phage and its genetic determinants" (by E, Kellenberger); The analysis of 

 regulatory mechanisms in cell differentiation (by L. Sachs); "Genetic aspects 

 of neoplasia" (by G. Klein); and "Cell differentiation and the immune 

 mechanism" (by M. Feldman et al.). The paper by Sachs discusses the in vitro 

 differentiation and function of lymphocytes, cell interactions involved in 

 growth control in vitro (using antigenetic cell markers), and the problem of 

 irreversible differentiation (ribosome programming, DNA-RNA hybridization 

 and somatic cell hybridization). The paper by Feldman et al. is concerned 

 with the differentiation in vivo of immunologically competent cells, and with 

 the in vitro differentiation of muscle cells and its relationship to RNA synthe- 

 sis. 



The book is well-printed and adequately illustrated. It is concluded by a 

 subject index. An author index and a list of contributors are lacking. 



Contributors: Anfinsen (Bethesda, Md.), Bennett (New York, N.Y.), Chain (Rome), 

 Chargaff (New York.N.Y.), Conway (New York, N.Y.), Edsall (Cambridge, Mass.), Elson 

 (Rehovoth), Feldman (Rehovoth), Gierer (Tubingen), Globerson (Rehovoth), Goldstein (New 

 York, N.Y.), Heidelberger (New Brunswick, N.J.), Katchalski (Rehovoth), Kellenberger 

 (Geneva), Kendrew (Cambridge), Klein (Stockholm), Lipmann (New York, N.Y.), Lynen 

 (Munchen), Nachmansohn (New York, N.Y.), Nakamoto (New York, N.Y.), Neurath (Seattle, 

 Wash.), Ochoa (New York, N.Y.), Sachs (Rehovoth), Sela (Rehovoth), Spyrides (New 

 York, N.Y.), Theorell (Stockholm), Weber (Heidelberg), Yaffe (Rehovoth). 



48. MECHANISMS OF NEURAL REGENERATION 



1964 



Editors: M. Singer and J. P. Schade Elsevier Publishing Cy. 



Progress in Brain Research, vol. 13 Amsterdam - London - New York 



241 pp., 116 figs., 11 tbs. Price: 80 s. 



This report contains a series of eight lectures delivered during a "workshop" 

 which was held as part of the first International Summer School of Brain 

 Research in Amsterdam, July 1963. Of the nine contributors four came from 

 the U.S.A. and five from European countries. 



Some of the lectures are rather specialized, but others are of more general 

 significance for developmental biologists. This holds particularly for the fol- 

 lowing articles: 1. "Neurotrophic relations in the regeneration process", by E. 

 Gutmann (41 pages), which includes a discussion of changes of neurotrophic 

 relations during morphogenesis; 2. "Development, degeneration and regener- 

 ation of receptor organs", by J. Zelena (37 pages), which deals with taste 

 organs, lateral line organs, cutaneous and muscle receptors; 3. "Nerves as 

 morphogenetic mediators in regeneration", by H. A. L. Trampusch (14 pages), 

 which reports on experiments in axolotl limb regeneration. 



To workers themselves active in the fields of regeneration or neuro-embryo- 

 logy most of the other articles will also prove valuable. They discuss such 

 subjects as axoplasmic streaming and phospholipid transport, the influence of 



362 



