331 



Granulation Tumors. 



1. Mule with granulating "sores" on rib region and on 

 breast. In curetting away the exuberant growths a slight 

 grittiness was perceptible, indicating calcareous degenera- 

 tion ; this made the growths more consistent and more 

 definitely granular. Another peculiar characteristic was 

 observed ; this hard granular growth extended quite a dis- 

 tance under the skin, and could be easily removed by push- 

 ing the curette up under the skin. After removing as much 

 of the granular growths as possible with the curette, strong 

 carbolic acid was applied and the following was prescribed : 

 Carbolic acid, 2 drachms ; Iodoform, 1 drachm ; Tannic 

 acid, 1 ounce ; Glycerine, 1^ pints. Mix. Apply daily after 

 washing. In 4 or 5 weeks the wounds had all healed and 

 there were no more signs of their return that year. But the 

 next spring " the same kind of sores broke out all over the 

 body and got so bad that I took the mule off and killed 

 him" (owner). 



2. Bay mule, 6 years old, with exuberant granulations 

 on inside of left hind pastern. Cut it off even with the sur- 

 face, applied pulverized copper sulphate and then a band- 

 age. As soon as the bandage was removed the mule was 

 worked ; the opposite foot struck the raw surface and the 

 mule habitually gnawed it. Consequently, new growths 

 were removed from this place eight times during the next 

 two years. At present (June, 1896) a new growth as large, 

 or larger than, any that were removed from the same 

 place is now to be found ; also, another tumor of the same 

 nature has appeared, and has been removed 3 or 4 times, on 

 the inner surface of the upper end of the canon region of the 

 same leg. Microscopical sections of these tumors show that 

 they are made up largely of embryonal cells not unlike the 

 spindle cells of a sarcoma. 



In one sense this tumor might be called a malignant, 

 spindle-celled sarcoma. However, it is best to regard it as 

 resulting and recurring from mechanical irritation, and 

 most probably extending from the same cause. It is well 

 to add that the mule was kept quiet only a short time dur- 



