CONTENTS. 



Part I. 



Page. 



Introduction 11 



Basic principles 23 



The respiratory quotient and its significance 23 



Indirect calorimetry 27 



Basal metabolism 30 



Apparatus and methods used in this research 31 



Respiration apparatus 32 



Methods of testing the respiration apparatus 44 



Tests for tightness 44 



Alcohol check tests 46 



Complete short-period alcohol check tests 47 



Details of typical quantitative alcohol check test 51 



Method of determining the degree of muscular repose 55 



Apparatus used in the respiration experiments 55 



Ward crib recorder 59 



Method of recording the pulse-rate 61 



General technique of respiration experiments with infants 62 



Part II. 



Statistics of observations 67 



Selection of subjects 67 



Hospital records 68 



Typical record 68 



Summarized hospital records for the other subjects 72 



Clinical status of infants 83 



Results of observations on the gaseous exchange 83 



Part III. 



Discussion of results 105 



Pulse-rate 106 



Preliminary observations 107 



Records obtained during observations with the respiration apparatus 118 



Relationship between pulse-rate and muscular activity 118 



Effect of changes in activity on the pulse-rate at different ages with the 



same infant 126 



Effect of changes in activity on the pulse-rate with infants of the same 



weight but different ages 127 



Effect of changes in activity on the pulse-rate with infants of the same age 



but with different body-weights 128 



Relationships of the muscular activity, pulse-rate, and metabolism 130 



Observation with J. V., February 27, 1913 130 



Observation with J. V., April 22, 1913 132 



Observation with A. L., June 28, 1913 133 



Observation with F. M., February 20, 1913 134 



Observation with M. M., June 5, 1913 135 



Observation with F. K, May 2, 1913 136 



Significance of the relationships 137 



Relationship between pulse-rate and metabolism 138 



Basal metabolism of infants studied 141 



Selection of data used for comparison. 142 



Minimum extraneous muscular activity 144 



Minimum influence of food 145 



5 



