Dissertations 



95. 



U. P. van der WAL. 1974. DE MOBILIZATIE VAN DE DOOIER VAN LYMNAEA 

 STAGNALIS L. (The mobilization of the yolk oi Lymnaea stagnalis L.) 

 Ph.D. thesis, Utrecht. 82 pp., 9 figs., 5 graph., 1 tab. English summary (2 pp.) (mimeo- 

 graphed) 



Early cleavage stages; ultrastructure of transforming yolk granules; localization of 

 newly synthesized proteins in transforming yolk granules (^H-leucine incubation and 

 EM-autoradiography); discussion of enzyme function in yolk granules; numerous excel- 

 lent electron micrographs and EM-autoradiographs. 



Symposium reports 



96. 



B. CLARKSON and R. BASERGA, eds. 1974. CONTROL OF PROLIFERATION IN 



ANIMAL CELLS 



Cold Spring Harbor Lab., Cold Spring Harbor. Cold Spring Harbor Conferences on Cell 

 Proliferation vol. 1 . XIV, 1029 pp., 385 figs., 220 tabs., subject index. $ 30.00 



This is the report of the first conference on cell proliferation held at the Cold Spring 

 Harbor Laboratory. It was an experiment, but a highly successful one. Here one finds in 

 one mammoth volume a cross section through nearly all the new frontiers of this 

 relatively young branch of biology. Almost all the leading investigators were there, most 

 of them from North America but with a sizeable proportion from other parts of the 

 world, particularly the United Kingdom, Switzerland (Basel), and Israel (Rehovot). 



The 78 brief to medium-length papers are arranged in five sections as follows: Growth 

 factors (11 papers). Viral transformation, revertants, and mutants (7), The cell surface 

 (27), Biochemistry of the cell cycle (20), and Prohferation kinetics, differentiation, and 

 external influences (13). Most, but by no means all papers deal with hemopoietic cells, 

 lymphocytes, and fibroblasts, and about half report work on normal rather than neoplas- 

 tic cells. As is brought out in the concluding summary by Stoker, most of the conference 

 dealt with three main aspects: the incoming signals, the role of the cell surface, and 

 intracellular switches and responses. 



The book is well produced at a reasonable price. The subject index is extensive. 



97. 



R. L. DAVIDSON and F. F. DE LA CRUZ, eds. 1974. SOMATIC CELL HYBRIDIZA- 

 TION 

 Raven, New York. XVI1I,295 pp., 58 figs., 57 tabs., author and subject indexes. $ 23.25 



This international conference was held in March, 1973 in Winter Park, Fla. It was 

 attended by 48 speciaUsts from the U.S.A., the United Kingdom, and various Western- 

 European countries. All the major areas of research involving cell hybridization were 

 covered. The discussions held at the conference are included, complete with literature 

 references. 



The 33 papers are arranged in four sections as follows: Chromosome segregation and 

 gene linkage in hybrid cells (8 papers). Viruses, cell membranes, and malignancy in fused 

 cells (5), Regulation of gene expression in hybrid cells (16), and Gene expression in 

 heterokaryons (4). Clearly the last two sections are of most interest to developmental 

 biologists. Section III is opened by a review on the control of expression of differentiated 

 functions in cell hybrids by Davidson (20 pp.), and contains a commentary by Ephrussi in 

 which he calls attention to the fundamental enigma of embryonic determination. Section 

 IV starts with a review on the regulation of gene expression in heterokaryons (with 



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