14 



THE NEW YORK JOURNAL OF PHARMACY 



ether is added to make the liquid 

 measure 20 com. This is now shaken 

 out with 10 com. of 10/10 H2SO4 v. 

 s.. shaking for a period of 5 minutes. 

 After standing for Vj an hour, the 

 acid liquid is collected in a cylinder, 

 and the washing or shaking out, twice 

 repeated with 3 ccm. of water. 



The combined extracts are then 

 titrated with N/io KOH, V. S., using 

 haematoxylin as indicator. 



I ccm. of the deci-normal acid is the 

 equivalent of: 



• 0.03 gm. of crystalline morphine 

 0.0289 gm. of anhydrous 

 0.0376 gm. of crystalline morphine 

 sul]ihate. 



Adulterated Oleic Acid. 



Von A. Roy, reports on two lots of 

 Oleic Acid, each of which was found 

 to be grossly adulterated. In the one 

 sample the adulterant was found to 

 be paraffin oil, while in the other both 

 paraffin and fish oils were found. 



5 grammes of the sample were 

 treated with 38 ccm. of 95% alcohol 

 and 2.50 gm. of potassium hydroxide 

 dissolved in a minimum cjuantity of 

 water. This mixture was boiled on a 

 water-bath, with reflux condenser, for 

 a period of ^ of an hour, after which 

 25 ccm. of water were added and the 

 mixture allowed to cool. After cool- 

 ing, the mixture was exactly neutral- 

 ized with hydrochloric acid, and then 

 just enough alkali added to produce a 

 faint alkaline reaction. 



The mixture was then shaken out 

 with 50 ccm. of petroleum ether. 25 

 ccm. of the ethereal layer were vapor- 

 ized (Ml the water-bath, the residue 

 dried for one hour at 100° — 105° C, 

 and then weighed. The residue equalled 



0.87 gm. and consiste<l of a clear and 

 non-saponifiable oil. In per cent, this 

 equals 34.80%. 



In another sample the Iodine num- 

 ber, after treatment for 18 hours with 

 the idodine reagent was found to be 

 137, thus showing the presence of sub- 

 stances capable of adding on much 

 more iodine than is possible for a pure 

 sample of oleic acid. The odor of 

 this latter sample was fishy, and at 

 once causes suspicion. The quantit\' 

 of fish oil added was found to be about 

 16%, and the quantity of paraffin oil 

 about 4.2%. 



Substitute for Tincture of Iodine in 

 Surgical Practice. 



Prof. Dr. C. Bachem Bonn, pro- 

 posed the following : — The preparation 

 of a tablet in which is contained 

 sodium iodide and sodium nitrate. In 

 another tablet is contained tartaric 

 acid. The quantities are so arranged 

 that when the tablets react with one 

 another in presence of water, exactly 

 0.485 gm. of iodine is produced, the 

 (piantity of water being 10 ccm. Mod- 

 erate agitation will cause the tablets 

 to dissolve and interact. The reaction 

 is known to be completed when oxides 

 of nitrogen cease to be evolved. Prof. 

 Dr. Bachem justifies this method of 

 procedure, because Tincture of Iodine 

 prepared in accordance with the form- 

 ula of the D. A. B., Y. 1910, is not 

 stable. 



A Method for the Estimation of Resin 

 in Sodium Soaps. 



Leiste and Stiepel. in Chem. Rev. 

 ue. d. Fett-u-Harzindustrie, 1913, 304, 

 ])ropose a method which is based on 

 the sohdiility of resin soaps in acetone, 



