THE NEW YORK JOURNAL OF PHARMACY 



13 



The same experiments were made re- 

 peatedly, always with the same result. 

 Pfaii, therefore, arrived at the conclusion 

 that under ordinary circumstances the 

 Eschbach method is a perfectly safe pro- 

 cedure for the determination of albumin 

 in presence of hexamethylentetramin. 



In presence of quantities of hexame- 

 thylentetramin above 0.5%, the method 

 may fail, as in such cases it has been 

 shown by Moschatos and Tollens, Lie- 

 big's, Annalen, 272, that hexamethylen- 

 tetramin is capable of forming a double 

 salt with tri-nitro-phenol. 



Cod-Liver Oil With Iodine. 



K. Tschanter, in Phar. Zeit., 1914, 9, 

 reports the following: An examination 

 of numerous samples, obtamed from dif- 

 ferent sources, show the presence of 

 more than traces of free iodine. This 

 was found to be so, quite independent of 

 the manner in which the sample had been 

 kept. It is necessary that the solution of 

 ferrous iodide before mixing with the 

 oil, be tested for free iodine, with starch, 

 in the customary manner. The combi- 

 nation of iodine with iron takes place 

 much slower in alcoholic solution than in 

 aqueous solution, requiring hours for 

 completion of reaction. Application of 

 heat does not materially influence the 

 rapidity of the combination. Such solu- 

 tions of ferrous iodide are rarely green, 

 but usually are yellow-green. The usual 

 directions to allow the reaction to pro- 

 ceed until the mixture has acquired a 

 green color are stated by Tschanter to be 

 at fault, they should read: Allow the 

 reaction to proceed until free iodine is 

 no longer found present. 



In order to produce an oil which will 

 remain permanently clear, cod-liver oil 

 wliich has not been exposed to air must 



be selected. This is imperative, as other- 

 wise a decomposition of the product may 

 be soon expected. As is known, cod-liver 

 oil has the property of absorbing oxygen 

 in considerable quantity, and this in turn 

 will react with the ferrous iodide. 



It is suggested that the required quan- 

 tity of cod-liver oil be withdrawn from 

 an heretofore unopened package, and be 

 immediately mixed with the required 

 quantity of the solution of ferrous iodide. 

 The latter is usually 5% strong, and is 

 known under the title of lodurol. The 

 resulting mixture is transferred to con- 

 tainers of proper size, which in turn are 

 well-stoppered. 



The preparation obtained in this man- 

 ner is perfectly clear and will remain so 

 for years. 



If it is desired to add a sweetening 

 agent, this must not be added to the 

 finished product, but rather to the solu- 

 tion of the ferrous iodide, before this is 

 added to the cod-liver oil. It was for- 

 merly customary to employ an excess of 

 iron and likewise to place a small quan- 

 tity of reduced iron or iron filings in 

 each container of iodurol. 



The commercial article at present, 

 liowever, is furnished without such ex- 

 cess or addition. It represents a light 

 green, perfectly clear liquid, and like 

 solution of ferrous iodide, it contains 5% 

 the salt. 



Four parts of iodurol are mixed with 

 96 parts of cod-liver oil, thus producing 

 a mixture containing 0.2% of ferrous 

 iodide. 



Misbranding. 



It would seem that in foreign coun- 

 tries, including Germany, in spite of 

 stringent laws and regidations to the 

 contrary, misbranding it not at all un-- 



