90 THE JOURNAL OF PHARMACOLOGY. 



gowski and other investigators have determined beyond all dispute the 

 bactericidal power of the leucocyte. 



The experiments by Stokes and Wegerath go to show thai filtered serum 

 is deprived of its bactericidal qualities, and that the presence of a sediment 

 consisting of grannies, leucocytes and red corpuscles restores to the serum 

 its germicidal power. 



It being therefore demonstrated that the Leucocytes not only contain a 

 bactericidal substance, but that under certain circumstances they can im- 

 part it to the surrounding medium, experimental proof is sought to show 

 thai the germicidal substance and the material that leaves the leucocyte 

 are identical. 



This proof is, of course, very difficult to obtain. These investigators 

 are. however, satisfied that in the observed separation of these granules 

 from the leucocyte this is confirmed. 



The bearing of these facts upon immunity is important, and induces 

 the writers to advance the following theory: "The bactericidal power of 

 the Leucocyte of the blood, and of the serum of man and many animals, is 

 due to the presence of specific granules, especially the eosinophilic and 

 neutrophilic. When called upon to resist the action of invading bacteria, 

 the granular Leucocytes can give up their granules to the surrounding 

 fluids or t issues." 



To the genera] practitioner the bearing of such conclusions as these is 

 of high significance. They emphasize tlie great importance of hematology 

 as a branch of clinical diagnosis. Already the facts of leucocytosis have 

 to be considered in estimating the prognosis of many diseases. In the 

 near Future the microscope may give us not only valuable means of measur- 

 ing the vis retentiae of the patient, but may enable us also to make confi- 

 dent predictions as to his immunity. — Med. Age. 



CREALBIN. 



A combination of creolin and albumin, resembling ichthalbin ami tan- 

 nalbin, has been introduced by Risselada (Pharm. Ztg., Vol. XLIL, p. 846) 

 under the name of "Crealbin." It is said to be obtained by precipitating 

 with diluted hydrochloric acid a mixture of lo parts of a 10-per-cent. solu- 

 tion of dried albumin with 1 pail of creolin mixed with lo parts of water. 

 The precipitate is dried on a water-hath, powdered, and subjected to further 

 heat in a. drying-closet at a temperature of from 115 degrees to L20 degrees 

 ( '. for three hours. One h undred parts of albumin yield about 1 on pails of 

 crealbin. 



The new preparation is intended for internal administration, but reports 

 regarding its use are still wanting. 



