-g THE JOURNAL OF PHARMACOLOGY. 



gnu), as a gradual central paralyzant, without any convulsive action. On 

 fowls there is a change in the circulation, which produces a violet coloration 

 of the comb, followed by a dry gangrene. It causes a decided gastro-en- 



eritis in Fowls, clogs and cats. In dogs, cats and guinea-pigs it produces 

 great restlessness. In pregnant animals doses of from 0.1 to 0.2 gin. (1J 

 „o 3 grn.) produce regular contraction of the uterus, resulting in abortion. 

 It slightly raises the Mood pressure. Elimination takes place for the most 

 part through the intestinal canal. Xo convulsive action of any kind was 



Loticed. Secalintoxine, the compound of secaline and sphaeelotoxine, 



is obtained by shaking the ethereal extract of the first precipitation, by 

 petroleum spirit, with dilute acetic acid, and adding sodium carbonate, when 

 i grayish precipitate is thrown down, which by subsequent washing can be 

 obtained as an almost colorless powder. This contains nitrogen, is freely 

 soluble in alcohol and in acetic ether, insoluble in petroleum spirit, [ts 

 formula is C 13 H 24 N 2 3 . 



Secaline was obtainable in a pure state, and its formula calculated as 

 C.. 1 H r ,.-,N,,O u . It. was physiologically inactive. Jacobi believes this to be 

 a pure form of [Robert's cornutine, bui not the same as Tanret's ergotinine, 

 which he thinks is more like his secalintoxine. 



The pharmaco-dynamics of secalintoxine is similar in most respects to 

 that of the chrysotoxine, the difference being quantitative rather than quali- 

 tative. The action on the uterus is less energetic, and the accompanying 

 irritation of the intestinal canal more marked. Thus, it is to he nod d that 

 chrysotoxine is the preferable combination to use. and that probably a 

 sodium preparation of this will give the best results on the uterus with a 

 minimum amount of stomach disturbance. 



A CASE OF HYOSCINE INTOXICATION. 



By Augustus A. Esiiner. M. D. 

 Professor of Clinical Medicine in the Philadelphia Polyclinic, Physician to the Philadelphia 



Hospital, etc. 



llvoseine is in many respects such a useful dru^. and one so extensively 

 •mployed, that any untoward effects resulting from its medicinal employ- 

 ment seem deserving of record. 1 wish in this connection to relate briefly 

 •he case of a. man. fifty-five years old. lor many years a sufferer from 

 asthma, who received at L0 P. .M.. by hypodermic injection. Tor the relief 

 of a spasm: 



Morphine sulphate. L-8 -rain: 



Strychnine sulphate. L-60 grain; 



1 1 s'oscine hvdrobromate, 1-lou grain. 



