THE JOURNAL OF PHARMACOLOGY. 169 



Some New Quinine Salts. — Quinine glycerophosphate (C 3 H 7 3 P0 3 : 

 [C 20 H24N 2 O 2 ] 2 ) is a white powder, soluble in hot water and in alcohol, 

 containing 68 per cent, of quinine. The neutral salt is hygroscopic and 

 is, therefore, generally replaced by the permanent basic salt. Both are 

 employed as tonics. 



Quinine phospho-muriate forms colorless crystals, soluble in 2 p. of 

 water and containing 50 per cent, of alkaloid. It is recommended in ob- 

 stinate cases of malaria and nervous headaches, as a substitute for quinine 

 sulphate, but on account of its lower alkaloidal strength must be given in 

 larger doses. [Pharm. Post, 1898, p. 131.] R. F. 



Cocaine Hydroidate.— This cocaine salt (Cj 7 H 21 N0 4 HI) is recom- 

 mended as a substitute for cocaine hydrochlorate in dental surgery for 

 accomplishing electro-anaesthesia fkataphoresis). This comparatively re- 

 cent therapy consists in introducing local anaesthetics into the tissues by 

 means of the electric current, without injury to the tissues. Kataphoresis 

 obtained with guaiacol-cocaine in 20 per cent, solution and the application 

 of a current of 0.2-4. milli-amperes for seven minutes caused complete 

 anaesthesia lasting for 15 minutes. The patients remain perfectly con- 

 scious and do not feel the current nor the slightest pain during the opera- 

 tion (extraction of a tooth, etc.). [Ph. Post, 1898, p. 131.] R. F. 



Acidity of Urine. — P. A. Lamanna considers the acidity of the urine as 

 a means to ascertain the acidity, hypoacidity or hyperacidity of the juices 

 of the body. The acidity of the urine is ascertained by supersaturation 

 with yi^N.— KOH and back titration using phenolphthaleine as indicator. 

 The normal urine of 24 hours contains acid : 



Calculated as H 3 P0 4 g. 1 —1.2 p. c. 



" HC1 g. 1.1 —1-35 " " 



" CoH 2 4 g. 1.9 -2-33 " " 



" H 2 S0 4 g. 1.47 — 1.81 " " 



[Chem. Centrbl. 69, I, p. 793-] 



Iodothymoform. — Is obtained by iodizing thymoform, and occurs as a 

 yellow powder, rich in iodine and practically odorless. It is very soluble 

 in alcohol and ether, and melts at about i50°C, thus permitting gauzes 

 impregnated with it to be thoroughly sterilized. 



Lycoctonin. — This is an alkaloid obtained from Aconitum Lycoctinum, 



Marchetti reports that it is a weak heart poison. In doses of 75 eg. per 



kilo of body weight it proved fatal in cases of cold blooded animals ; in 



warm blooded animals much larger doses are required. On the nervous 



system it exerts a paralytic action. Its color is yellowish white, and it is 



with difficulty soluble in water, but more readily so if dilute acetic or tar- 



tartic acids are present. 



G C. D. 



