THE AL UMNI JO URN A L . 



151 



ous feel ; carefully heated it melts at a little below 

 50 C. (122 F.) to a yellowish mass, which 

 easily gives off iodine; triturated with water and 

 filtered, the filtrate, on the addition of fuming 

 nitric acid, produces a blue coloration with 

 starch paste; heated with lime it emits the 

 characteristic odor of isobutylcresol. 



Lactophenin ; Bitterish crystals melting be- 

 tween 117. 5 and 118 C. (211. 5 and 212 4 F.); 

 0.1 Gm. boiled for one minute with 1 C.c. of 

 hydrochloric acid, then diluted with 10 C.c. of 

 water, cooled and filtered, produces a ruby-red 

 coloration on the addition of 3 C.c. of solution 

 of chromic acid; 0.1 Gm. dissolved in 10 C.c. of 

 hot water, cooled and filtered, yields a filtrate 

 which is rendered very turbid when bromine 

 water is added until the solution acquires a yel- 

 low color; this turbidty, however, disappears 

 when a large quantity of water is added, 



Levulose. (Diabetin) : White, or light yel- 

 lowish, friable mass, possessing a sweet taste; on 

 adding to its aqueous solution, first, solution of 

 calcium chloiide, then ammonia until alkaline, 

 and finally acetic acid until of an acid reaction, 

 the liquid remains clear. Its aqueous solution 

 (1 : 10), introduced into a 200 m. m : tube of a 

 polarizer, turns the plane of polarization at 

 least 1 6° to the left. 



Loretin (Orthooxyquinolinemetaidoalphasul- 

 phonic acid): Yellow, odorless powder; slightly 

 soluble in water or alcohol at ordinary tempera- 

 ture; insoluble in ether, benzol or chloroform; at 

 250 C. (482 F. ) it assumes a brown color, and 

 260 to 270 C. (500— 518 F.) it begins to decom- 

 pose with the emission of iodine vapors ; ferric 

 chloride produces an intense green coloration. 



Losophan (Triiodometacresol ) : White, crys- 

 talline powder, which is insoluble in water, 

 difficulty soluble in alcohol, readily soluble in 

 ether, benzol and chloroform, or fatty oils; 

 melting point, 121.5° C. (250.7 F. ); heated, it 

 gives off vapors of iodine; concentrated solution 

 of sodium hydroxide changes it to a greenish - 

 black, amorphous substance, which is no longer 

 soluble in alcohol. 



Lycetol (Dymethylpiperazine Tartrate) : 

 White, odorless powder, easily soluble in 

 water ; melting-point, 243° C. (469-2° F - ) \ solu " 

 tion has an acid reaction and a lemonade-like 

 taste ; heated with burnt lime it yields a distil- 

 late which contains free dimethylpiperazine, 

 the latter possessing, in a high degree, the 

 power of dissolving uric acid. 



Lysidin (Ethyleuethenyldiamine ; Methyl- 

 glyoxalidin) : White, very hygroscopic crystal- 

 line mass, of a peculiar odor : readily soluble in 



water, or alcohol, almost insoluble in ether ; 

 melting-point, 99-100° C, f2io.2-2i2° F. ) ; the 

 aqueous solution is strongly alkaline ; ferric 

 chloride produces a brown precipitate, and zinc 

 chloride a white one ; mercuric chloride precip- 

 itates a double salt, melting at 162° C. (323.6° 

 G.); on heating the solution with silver nitrate, 

 a precipitate of metallic silver is formed. 



Malakin (Salicylaldehyd-Paraphenetidine) : 

 Yellow, odorless, tasteless needles, melting at 

 92° C. (197.6° F.) ; very little soluble in water, 

 but soluble in hot alcohol or ether ; on pro- 

 longed boiling with water, or on the addition of 

 acids, or acid salts, the characteristic odor of 

 salicyl aldehyde is evolved ; if 0.5 Gm. of finely 

 pulverized malakin is mixed with 20 or 25 Cc. of 

 boiling water, shaken, cooled and filtered, the 

 filtrate gradually yields, on the addition of 1 or 

 2 drops of ferric chloride solution, a dirty-violet 

 color (salicyl aldehyde) or a cherry-red color 

 (phenetidine). 



Migranin (Antipyrine, Caffeine Citrate) : 

 White powder, readily soluble in water; gives 

 the reactions of both antipyrine and caffeine ; 

 distinguished from antipyrine by the fact that 

 its aqueous solution, on the addition of a solu- 

 tion of sodium nitrate, acquires a greenish 

 coloration without the need of the addition of 

 an acid. 



Phenocoll Hydrochlorate ( Amidoacetparaph- 

 enetidine Hydrochlorate) : White, light powder, 

 consisting of minute needles of a sweetish taste; 

 0.5 Gm. forms a clear solution with 15 C.c. of 

 water ; soda solution precipitates the phenocoll 

 base, as a white crystalline mass ; its solution, 

 boiled for a few minutes with a few drops of 

 hydrochloric acid, gives all the reactions, 

 though more faintly, which phenacetine ex- 

 hibits under similar conditions. 

 (To be continued?) 



Malakin. — (Salicyl aldehyd para phenetidin 

 has been used by Abernethy, (Edinburgh Med. 

 Jour. Feb 1895). in the pyrexia of rheumatism 

 and pneumonia. 



It is indicated in cases where the phenacetine 

 or salicylic group have been found beneficial, 

 especially the latter. Its administration in the 

 writer's experience has not yet been altered 

 with any bad results. The dose for an adult is 

 fifteen grains three times a day. 



Malakin is decomposed by the action of weak 

 inorganic acids into salicylic aldehyd and para 

 phenetidin. This change occurs when malakin 

 s taken into the stomach, and according to 

 Schmudenberg, the salicylic aldehyd changes to 

 salicylic acid and may be detected in the urine- 



