﻿Commissioner 
  of 
  Agriculture. 
  513 
  

  

  Two 
  developed 
  rabies 
  in 
  twenty-three 
  and 
  twenty-seven 
  days 
  re- 
  

   spectively, 
  the 
  others 
  were 
  killed 
  forty 
  days 
  after 
  inoculation, 
  with- 
  

   out 
  any 
  symptoms 
  of 
  rabies." 
  

  

  Respectfully 
  submitted, 
  

  

  WM. 
  HENRY 
  KELLY, 
  Y. 
  S. 
  

  

  BOVINE 
  TUBERCULOSIS. 
  

   Is 
  THE 
  Bacillus 
  Tuberculosis 
  of 
  Cattle 
  Permanently 
  Dif- 
  

   ferent 
  FROM 
  THAT 
  OF 
  MaN? 
  

  

  By 
  JAMES 
  LAW, 
  F. 
  R. 
  C. 
  V. 
  S., 
  

  

  DIRECTOR 
  OF 
  THE 
  NEW 
  YORK 
  STATE 
  VETERINARY 
  COLLEGE. 
  ITHACA. 
  

  

  In 
  making 
  a 
  strictly 
  sanitary 
  survey 
  of 
  bovine 
  tuberculosis 
  one 
  

   may 
  as 
  well 
  avoid 
  questions 
  that 
  are 
  apt 
  to 
  be 
  more 
  or 
  less 
  

   misleading 
  if 
  treated 
  as 
  mere 
  biological 
  studies 
  unless 
  they 
  are 
  

   material 
  to 
  the 
  practical 
  work 
  of 
  sanitation. 
  The 
  question 
  of 
  

   difference 
  in 
  species 
  or 
  variety 
  of 
  the 
  germ 
  cannot 
  interest 
  us 
  

   until 
  we 
  get 
  an 
  authoritative 
  decision 
  as 
  to 
  what 
  a 
  species 
  means. 
  

   The 
  permanence, 
  however, 
  or 
  variability 
  of 
  a 
  germ 
  as 
  regards 
  its 
  

   pathogenesis 
  has 
  a 
  direct 
  and 
  constant 
  bearing 
  on 
  sanitary 
  work, 
  

   and 
  is 
  not 
  to 
  be 
  obscured 
  by 
  any 
  other 
  question 
  which 
  does 
  not 
  

   involve 
  this 
  important 
  issue. 
  

  

  After 
  Koch's 
  discovery 
  of 
  the 
  bacillus 
  tuberculosis, 
  in 
  1882, 
  it 
  

   was 
  assumed 
  that 
  all 
  known 
  forms 
  of 
  the 
  germ 
  were 
  essentially 
  

   identical 
  and 
  transmissible 
  from 
  animal 
  to 
  animal; 
  but 
  the 
  inocu- 
  

   lation 
  of 
  different 
  genera 
  and 
  of 
  cultures 
  in 
  different 
  media 
  and 
  

   under 
  varying 
  conditions 
  of 
  temperature 
  revealed, 
  in 
  successive 
  

   cases, 
  a 
  very 
  unequal 
  capacity 
  for 
  growth 
  and 
  pathogenesis, 
  which 
  

   indicated 
  decided, 
  if 
  even 
  temporary, 
  biological 
  changes. 
  Arti- 
  

   ficial 
  culture 
  media 
  were 
  seeded 
  with 
  difficulty 
  with 
  the 
  manunal- 
  

   grcwn 
  bacillus, 
  though 
  after 
  one 
  or 
  two 
  generations 
  it 
  might 
  hf^ 
  

  

  33 
  

  

  