﻿Commissioner 
  of 
  Agriculture. 
  523 
  

  

  were 
  killed 
  after 
  four, 
  eight, 
  and 
  twelve 
  niontlis 
  respectively, 
  and 
  

   had 
  severally 
  53, 
  63 
  and 
  13 
  nodnles 
  on 
  the 
  small 
  intesitine, 
  mostly 
  

   on 
  Peyer's 
  patches. 
  Two 
  calves 
  received 
  at 
  one 
  dose 
  440 
  c. 
  c. 
  of 
  

   tuberculous 
  sputum, 
  and 
  were 
  severally 
  killed 
  after 
  eight 
  and 
  nine- 
  

   teen 
  weeks. 
  The 
  first 
  had 
  tubercular 
  nodules 
  in 
  the 
  intestine 
  and 
  

   mesenteric 
  glands.^ 
  

  

  Frothingham 
  injected 
  into 
  the 
  peritoneum 
  of 
  two 
  calves, 
  three 
  

   and 
  thirteen 
  weeks 
  old, 
  a 
  culture 
  of 
  tubercle 
  bacilli 
  isolated 
  one 
  

   year 
  before 
  from 
  the 
  liver 
  of 
  a 
  child. 
  Slight 
  local 
  nodules 
  were 
  

   produced, 
  some 
  like 
  spontaneous 
  tubercle, 
  others 
  granulation 
  tissue. 
  

  

  Theobald 
  Smith 
  inoculated 
  sputum 
  into 
  the 
  chest 
  and 
  abdomen 
  

   of 
  the 
  following: 
  

  

  1. 
  A 
  yearling 
  heifer, 
  which 
  was 
  killed 
  two 
  months 
  later 
  and 
  

   showed 
  on 
  the 
  pleura 
  near 
  the 
  seat 
  of 
  infection 
  a 
  mass 
  of 
  tubercles 
  

   one 
  by 
  one 
  and 
  a 
  half 
  inch 
  in 
  diameter, 
  with 
  partly 
  caseated 
  centres; 
  

   also 
  a 
  nodule 
  one-eighth 
  of 
  an 
  inch 
  on 
  the 
  right 
  lung, 
  and 
  small 
  

   tubercles 
  attached 
  to 
  the 
  diaphragm 
  and 
  omentum. 
  

  

  2. 
  A 
  yearling 
  injected 
  in 
  the 
  same 
  way 
  showed 
  in 
  two 
  months 
  

   on 
  the 
  diaphragm 
  a 
  mass 
  of 
  tubercles 
  two 
  inches 
  in 
  diameter, 
  and 
  

   a 
  second 
  mass 
  one 
  inch 
  in 
  diameter 
  on 
  the 
  ribs 
  near 
  the 
  seat 
  of 
  

   infection. 
  Microscopical 
  examination 
  failed 
  to 
  detect 
  bacilli, 
  but 
  

   there 
  is 
  no 
  evidence 
  that 
  they 
  were 
  sought 
  by 
  culture 
  or 
  inoculation. 
  

  

  3. 
  A 
  cow 
  injected 
  in 
  the 
  chest 
  and 
  killed 
  after 
  two 
  months 
  

   showed 
  tubercles 
  of 
  the 
  lungs, 
  pleura, 
  and 
  mediastinal 
  glands, 
  

   partly 
  caseated 
  and 
  containing 
  bacilli. 
  Vascular 
  fringes 
  hung 
  from 
  

   the 
  pleura. 
  

  

  4. 
  A 
  cow 
  receiving 
  a 
  chest 
  injection 
  of 
  sputum 
  culture 
  and 
  

   killed 
  in 
  two 
  months 
  sh'owed 
  fringes 
  and 
  pendulous 
  masses 
  on 
  

   the 
  pleura, 
  with 
  small 
  tubercles 
  containing 
  cheesy 
  matter 
  and 
  a 
  

   few 
  bacilli.^*^ 
  

  

  Crookshank 
  injected 
  tubercular 
  sputum 
  into 
  the 
  peritonenm 
  of 
  

   a 
  calf, 
  which 
  died 
  of 
  streptococcus 
  infection 
  on 
  the 
  forty-second 
  

   day. 
  It 
  showed 
  extensive 
  tubercular 
  deposits 
  in 
  the 
  seat 
  of 
  injec- 
  

  

  9 
  Report 
  of 
  Royal 
  Coirimission 
  of 
  1895. 
  

   10 
  Journal 
  of 
  Experimental 
  Medicine, 
  1898, 
  vol. 
  iii, 
  p. 
  482. 
  

  

  