﻿546 
  Seventh 
  Annual 
  Report 
  of 
  the 
  

  

  they 
  are 
  entirely 
  distinct 
  species. 
  Notwithstanding 
  the 
  numerous 
  

   statements 
  that 
  human 
  and 
  bovine 
  tubercle 
  bacilli 
  are 
  entirely 
  dif- 
  

   ferent 
  species, 
  there 
  is 
  nothing 
  in 
  the 
  results 
  of 
  the 
  investigations, 
  

   thus 
  far 
  published 
  to 
  support 
  such 
  an 
  extreme 
  statement. 
  

  

  In 
  order 
  that 
  we 
  may 
  not 
  misconstrue 
  the 
  results 
  of 
  Smith's 
  in- 
  

   vestigations 
  and 
  that 
  we 
  may 
  not 
  draw 
  unjustifiable 
  conclusions, 
  

   I 
  have 
  appended 
  his 
  own 
  statement 
  concerning 
  (1) 
  the 
  morphology 
  

   and 
  the 
  cultural 
  differences 
  of 
  these 
  bacilli, 
  and 
  (2) 
  the 
  pathogene- 
  

   sis 
  of 
  the 
  different 
  cultures 
  as 
  tested 
  on 
  a 
  variety 
  of 
  species 
  of 
  ani- 
  

   mals. 
  He 
  worked 
  with 
  pure 
  cultures 
  isolated 
  from 
  human 
  sputum, 
  

   tuberculous 
  cattle, 
  a 
  horse, 
  a 
  cat, 
  and 
  a 
  pig. 
  For 
  the 
  details 
  of 
  

   these 
  experiments, 
  the 
  reader 
  is 
  referred 
  to 
  the 
  original 
  article.^^ 
  

  

  " 
  I. 
  Concerning 
  morphology 
  and 
  cultures. 
  1. 
  Bovine 
  and 
  other 
  

   animal 
  bacilli 
  (except 
  nasiia, 
  which 
  is 
  regarded 
  as 
  coming 
  from 
  

   man) 
  grew 
  less 
  vigorously 
  for 
  a 
  number 
  of 
  generations 
  than 
  the 
  

   sputum 
  bacilli. 
  Sputum 
  I. 
  is 
  an 
  exception, 
  and 
  is 
  probably 
  an 
  

   atypical 
  form. 
  2. 
  Bovine 
  bacilli 
  are 
  much 
  less 
  influenced 
  by 
  cer- 
  

   tain 
  modifications 
  of 
  the 
  culture 
  medium. 
  3. 
  Bovine 
  bacilli 
  tend 
  

   to 
  remain 
  short; 
  human 
  bacilli 
  are 
  either 
  more 
  slender 
  from 
  the 
  

   stai't 
  or 
  become 
  so 
  during 
  cultivation. 
  

  

  " 
  II. 
  Results 
  of 
  inoculations 
  in 
  rahhits. 
  The 
  divergences 
  no- 
  

   ticed 
  when 
  rabbits, 
  weighing 
  between 
  1300 
  and 
  2200 
  gi-ammes, 
  are 
  

   inoculated 
  into 
  an 
  ear-vein 
  with 
  0.5 
  c. 
  c. 
  of 
  a 
  well-clouded 
  sus- 
  

   pension 
  of 
  tubercle 
  bacilli 
  in 
  bouillon 
  are 
  as 
  follows: 
  1. 
  Death 
  of 
  

   the 
  bovine 
  cases 
  in 
  seventeen 
  to 
  twenty-one 
  days. 
  2. 
  Eapid 
  evo- 
  

   lution 
  and 
  necrosis 
  of 
  the 
  pulmonary 
  tubercles, 
  with 
  very 
  great 
  

   increase 
  of 
  the 
  tubercle 
  bacilli 
  in 
  them. 
  3. 
  Death 
  of 
  the 
  sputum 
  

   rabbits 
  (one 
  explainable 
  exception) 
  did 
  not 
  ensue, 
  but, 
  after 
  one 
  

   and 
  a 
  half 
  to 
  three 
  and 
  a 
  half 
  months, 
  the 
  original 
  weight 
  had 
  

   been 
  more 
  or 
  less 
  exceeded. 
  4. 
  The 
  pulmonary 
  tubercles 
  in 
  the 
  

   sputum 
  rabbit 
  developed 
  very 
  slowly, 
  with 
  very 
  little 
  tendency 
  

   toward 
  necrosis. 
  Th-e 
  bacilli 
  were 
  present 
  in 
  very 
  small 
  numbers 
  

   only. 
  5. 
  The 
  swine 
  and 
  cat 
  cultures 
  are 
  to 
  be 
  classed 
  with 
  the 
  

   bovine; 
  the 
  horse 
  cultures 
  stand 
  intermediate. 
  

  

  21 
  Journal 
  of 
  Experimental 
  Medicine, 
  1898, 
  vol. 
  ill, 
  p. 
  451. 
  

  

  