﻿554 
  Annual 
  Report 
  of 
  Commissioner 
  of 
  Agriculture. 
  

  

  fore 
  the 
  injection, 
  as 
  one 
  may 
  have 
  to 
  deal 
  with 
  animals 
  who, 
  un- 
  

   der 
  the 
  influence 
  of 
  a 
  temporary 
  ailment 
  or 
  trifling 
  pathological 
  

   condition, 
  such 
  as 
  disorder 
  of 
  the 
  digestion, 
  present 
  great 
  oscilla- 
  

   tions 
  of 
  the 
  temperature; 
  hence 
  an 
  important 
  source 
  of 
  error. 
  

   In 
  the 
  case 
  of 
  these 
  animals 
  it 
  is 
  better 
  to 
  postpone 
  the 
  operation. 
  

   8. 
  In 
  certain 
  tuberculous 
  animals 
  which 
  are 
  not 
  feverish 
  the 
  re- 
  

   action 
  following 
  the 
  injection 
  of 
  tuberculin 
  hardly 
  exceeds 
  a 
  de- 
  

   gree. 
  Therefore, 
  as 
  experience 
  shows 
  that 
  in 
  perfectly 
  healthy 
  

   animals 
  the 
  temperature 
  may 
  undergo 
  variations 
  of 
  a 
  degree 
  and 
  

   more, 
  one 
  must 
  only 
  consider, 
  as 
  having 
  a 
  real 
  diagnostic 
  value, 
  

   reactions 
  of 
  more 
  than 
  1.4° 
  C. 
  An 
  elevation 
  of 
  temperature 
  of 
  

   less 
  than 
  eight-tenths 
  of 
  a 
  degree 
  has 
  no 
  meaning. 
  Every 
  animal 
  

   whose 
  temperature 
  undergoes 
  an 
  elevation 
  included 
  between 
  

   eight-tenths 
  of 
  a 
  degree 
  and 
  one 
  to 
  four 
  degi'ees 
  must 
  be 
  con- 
  

   sidered 
  under 
  suspicion, 
  and 
  mil 
  have 
  to 
  undergo, 
  after 
  an 
  inter- 
  

   val 
  of 
  a 
  month 
  or 
  so, 
  a 
  new 
  injection 
  of 
  a 
  larger 
  dose 
  of 
  tuber- 
  

   culin. 
  

  

  To 
  these 
  conclusions 
  the 
  following 
  must 
  be 
  added 
  : 
  

   (a) 
  Successive 
  injections 
  repeated 
  daily, 
  or 
  at 
  intervals 
  of 
  some 
  

   days, 
  give 
  reactions 
  gradually 
  less 
  intense. 
  There 
  is 
  produced 
  a 
  

   veritable 
  toleration 
  of 
  the 
  action 
  of 
  the 
  tuberculin. 
  My 
  experi- 
  

   ments 
  seem 
  to 
  establish 
  that 
  this 
  toleration 
  is 
  very 
  temporary. 
  

   In 
  the 
  case 
  of 
  several 
  tuberculous 
  cows 
  submitted 
  to 
  injections 
  

   every 
  fifteen 
  days, 
  every 
  twelve 
  days, 
  or 
  every 
  eight 
  days, 
  I 
  have 
  

   registered, 
  eight 
  or 
  ten 
  times 
  running, 
  rises 
  of 
  temperature 
  prac- 
  

   tically 
  equal. 
  

  

  (6) 
  The 
  tuberculous 
  calf 
  reacts 
  just 
  as 
  well 
  as 
  the 
  adult; 
  the 
  

   dose 
  should 
  vary 
  from 
  10 
  to 
  20 
  centigrammes. 
  

  

  (c) 
  The 
  injections 
  of 
  tuberculin 
  have 
  no 
  troublesome 
  effect 
  on 
  

   the 
  quantity 
  or 
  quality 
  of 
  the 
  milk 
  or 
  on 
  the 
  progress 
  of 
  gesta- 
  

   tion. 
  This 
  observation 
  is 
  the 
  result 
  of 
  a 
  considerable 
  number 
  of 
  

   experiments 
  made 
  on 
  cows 
  in 
  full 
  lactation 
  and 
  at 
  all 
  periods 
  of 
  

   gestation. 
  

  

  