OMe OMe 



(viii) 



yCHa— N O.COgEt 



CH. C— CH,— / \ 



OMe 



/ 



> / "— ^ CH3I 



\ / 



OMe OMe 

 CH3 



yCHa— N O.COgEt 



CH2 C— CHg— / \oMe 



\ / ' \__yuMe Sn + HCland 



_ ^ 



simultaneous 

 y hydrolysis 



OMe OMe 



CH 



3 



/CH,— N 

 CH2 CH— CH2— /~\OMe 



/Cn2— IN OH 



OMe OMe 



204 SCIENCE PROGRESS 



was converted into laudanine by ring closure, methylation, 1 

 reduction, and hydrolysis. 



CH2.CH2.NH2 

 OH O.COgEt I 



MeO^^^CHg.COaH-^MeO^^CHa.COaCl + /^ y 



OMe OMe 

 (v) (vi) (vii) 



/™2~NH O.COaEt 



CH2 C0.CH2(^0Me P2O5 



