280 



CHAPTER 31 



REFERENCES 



Beam, A. G., "The Chemistry of Hereditary Disease," Scient. Amer., 195:126-136, 1956. 



Ephrussi, B., "Chemistry of 'Eye Color Hormones' of Drosophila," Quart. Rev. Biol., 



17:327-338, 1942. 

 Harris, H., Human Biochemical Genetics, Cambridge University Press, 310 pp., 1959. 

 Hsia, D. Y.-Y., Inborn Errors of Metabolism, Chicago, The Year Book Publishers, 1959. 

 Wagner, R. P., and Mitchell, H. K., Genetics and Metabolism, New Yoric, John Wiley & 



Sons, 1955. 



Harriet Ephrussi-Taylor {see p. 

 341), Boris Ephrussi, and Leo Szilard 

 (see p. 336) at Cold Spring Harbor, 

 N.Y. in 1951. {Courtesy of the Long 

 Island Biological Association.) 



QUESTIONS FOR DISCUSSION 



31.1. List five diseases in human beings that are caused by inborn errors of metabolism. 



31.2. In what respect can an inborn error of metabolism be cured? 



31.3. Do all mutations produce inborn errors of metabolism? Explain. 



31.4. What evidence can you present that cistrons control different steps of a bio-synthetic 

 sequence of reactions? 



31.5. Has our study of recons and recon mutation been dependent upon the concept of a 

 cistron? Explain. 



31.6. Do you suppose that proof of the one cistron-one primary effect hypothesis would 

 reveal anything regarding the chemical properties of a gene? Explain. 



31.7. From which of these areas of investigation would you expect to obtain the most 

 information regarding the cistron — morphology, physiology, biochemistry? Why? 



31.8. Do you think that the concept of the cistron has any consequences for the practice 

 of medicine? Explain. 



31.9. In what way is our study of the cistron related to, or dependent upon, mutation 

 ' and recons? 



31.10. Discuss the evidence relative to the diffusibility of v+ substance and cn+ substance. 



