212 



CHAPTER 24 



REFERENCES 



MuUer, H. J., "A Semi-automatic 

 Breeding System ('Maxy') for 

 Finding Sex-linked Mutations 

 at Specific 'Visible' Loci," Dro- 

 sophila Info. Serv., 28:140-141, 

 1954. 



Muller, H. J., "The Nature of the 

 Genetic Effects Produced by 

 Radiation," in Radiation Biol- 

 ogy, Hollaender, A. (Ed.), 

 New York, McGraw-Hill, 1 : 

 Chap. 7:351-473, 1954. 



Schalet, A., "A Study of Spontane- 

 ous Visible Mutations in Dro- 

 sophila Melanogaster," Proc. X 

 Intern. Congr., Genetics, Mon- 

 treal, 2:252 (Abstr.), 1958. 



See Supplement III. 



H. J. Muller, at Cold Spring Harbor, 1941. 



QUESTIONS FOR DISCUSSION 



24.1. Are all of the mutants detected by the Base or Maxy techniques point mutants? 

 Explain. 



24.2. Suppose, in the Base technique, an F2 culture produced both expected types of 

 daughters, but no sons at all. To what would you attribute this result? 



24.3. How might you proceed to test whether a recessive lethal detected in the F^ of the 

 Base technique was associated with an inversion or a reciprocal translocation? 



24.4. A wild-type female produces 110 daughters but only 51 sons. How could you test 

 whether this result was due to the presence, in heterozygous condition, of a recessive 

 X-linked lethal? 



24.5. How can you explain the phenotype of a rare female in the Maxy stock that pro- 

 duces only the usual Maxy type of progeny, but which has both compound eyes 

 distinctly lighter than normal? 



24.6. Can the Maxy stock be used to detect the occurrence of visible mutants which arise 

 in the female germ line? Explain. 



Can the Maxy stock be used to detect the frequency of recessive lethal mutations 

 that arise in the male germ line? Explain. 



24.7. Compare the relative suitability of man and Drosophila for the determination of 

 mutation rates. 



24.8. The genes in the X chromosomes are incompletely linked in the females of the Base 

 stock, but completely linked in the females of the Maxy stock. Do you agree with 

 this statement? Why? 



24.9. Do you suppose that the general conclusions regarding the phenotypic effects of 

 mutants in Drosophila also apply in the case of man? Why? 



24.10. Reread the main part of this Chapter and write a Summary and Conclusions section 

 of less than 200 words without consulting the one given. Compare the two sections 

 critically and objectively. 



24.11. What is the relation between the gene and the phenotypic effect by which it is de- 

 tected? 



