318 



CHAPTER 34 



Crick, F. H. C, "Nucleic Acids," Scient. Amer., 197:188-200, 1957. 



Meselson, M., and Stahl, F. W., "The Replication of DNA in Escherichia Coli,^' Proc. 

 Nat. Acad. Sci., U.S., 44:671-682, 1958. 



Sueoka, N., "Mitotic Replication of Deoxyribonucleic Acid in Chlamydomonas Reinhardi,'''' 

 Proc. Nat. Acad. Sci., U.S., 46:83 90, 1960. 



Watson, J. D., and Crick, F. H. C, "Molecular Structure of Nucleic Acids. A Structure 

 for Deoxyribose Nucleic Acid," Nature, London, 171:737-738, 1953a; reprinted in 

 Classic Papers in Genetics, Peters, J. A. (Ed.), Englewood Cliffs, N.J., Prentice-Hall, 

 1959, pp. 241-243. 



Watson, J. D., and Crick, F. H C, "Genetical Implications of the Structure of Deoxyribo- 

 nucleic Acid," Nature, London, 171 :964-969, 1953b; reprinted in Papers on Bacterial 

 Genetics, Adelberg, E. A. (Ed.), Boston, Little, Brown, 1960, pp. 125-130. 



Watson, J. D., and Crick, F. H. C, "The Structure of DNA," Cold Spring Harbor Sym- 

 posia on Quantitative Biology, 18:123-131, 1953c; reprinted in Papers on Bacterial 

 Viruses, Stent, G. S. (Ed.), Boston, Little, Brown, 1960, pp. 193-208. 



James D. Watson in 1959. {Photographed by The Calvin Company.) 

 {Photograph of F. H. C. Crick is unavailable.) 



QUESTIONS FOR DISCUSSION 



34.1. Can you draw any conclusions from the observation that most of the multicellular 

 organisms studied are richer in A + T than C + G? 



34.2. Why is it expected, among the DNA molecules contained in a genome, that many 

 would differ in base sequence and content? 



34.3. How many different base pairs normally occur in a double helix of DNA? What 

 are these? 



34.4. If a coil is right-handed when looked at from one end, is it also right-handed when 

 seen from the other end? 



