VI CONTENTS 



Page. 



Pseudechis ng 



Distira 1 20 



Hydrophis 121 



^ Enhydrina 121 



Hydrus 121 



Opisthoglyphous Colubridae 122 



XII. Effect of Snake Venom upon the Nervous System and Effect of the Sequelae 



upon the Respiratory and Circulatory Functions 124-132 



Crotalinae 124 



Viperinas 129 



Elapinae 126 



Hydrophiinae 131 



XIII. Effects of Snake Venom upon the Coagulability of the Blood 133-142 



Anticoagulating Property of Snake Venoms 139 



XIV. Neurotoxins of Snake Venom 143-155 



Histological Changes Caused by Neurotoxins of Snake Venom 150 



Venom-neurolysis in vitro 150 



Cells of Sycotypus 151 



Histological Changes of Nervous System Produced by Snake Venom . . 152 



XV. Haemorrhagins of Snake Venom 1 56-161 



Plistological changes caused by Venom Haemorrhagins i6r 



XVI. Venom-haemolysis and Venom-agglutination 162-198 



Effects in vivo and in vitro 162 



The Nevi^ Era of the Study of Venom Haemolysis 169 



Mechanism of Venom Haemolysis 185 



Antihaemolytic Properties of Cholesterin 194 



XVII. Cytolysins in Snake Venom 199-205 



Effect of Venom on Cells of Warm-blooded Animals 199 



Effect of Venom on Cells of Cold-blooded Animals 201 



Cytolytic Action of Snake Venom on Micro-organisms 205 



XVIII. Histological Changes produced by Snake Venom on various Organs and 



Tissues 206-209 



Action of Snake Venom upon the Liver 207 



Action of Snake Venom upon the Kidney 208 



Action of Snake Venom upon the Lungs 208 



Action of Snake Venom upon the Spleen 208 



Action of Snake Venom upon the Heart 209 



Action of Snake Venom upon the Muscles 209 



XIX. Ferments in Snake Venom 210 



Proteolytic Action of Snake Venom 21 1-214 



Diastatic Actions of Snake Venom 213 



Lipolytic Action of Snake Venom 213 



XX. Antibactericidal Properties of Snake Venom 215-218 



XXI. Toxicity of the Tissues of Venomous Snakes 219 



XXII. Effects of Snake Venom on Mucous, Conjunctival, and Serous Membranes and 



Alimentary Tract 220-222 



XXIII. Artificial Immunization 223-232 



Active Immunity ■ — Prophylactic Inoculation 223 



Passive Immunity — Antivenins 225 



XXIV. Specificity and Therapeutic Values of Antivenins 233-245 



Specificity of Antivenins as a whole 233 



Specificity of Antivenins due to differences in the characteristic toxic 



principles of the venom of each species 233 



Specificity of Antivenins due to differences in individual cytotropic toxins 



of the venoms of different species 236 



Crotalus adamanteus Antivenin 239 



Crotalus terrificus Antivenin 240 



Ancistrodon piscivorus Antivenin 240 



Lachesis lanceolatus Antivenin 240 



Lachesis flavoviridis Antivenin 241 



Calmette's Antivenin 241 



Therapeutic Value of Antivenins 241 



XXV. Interactions between Venom and Antivenin 246-260 



Establishment of the Chemical Nature of Venom-antivenin Reaction 246 



Regeneration of Venom and Antivenin from their Neutral Combination 248 



