TOXIC SECRETIONS OF VENOMOUS SNAKES 



73 



Table i. — Continued. 



Species, etc. 



Viperidas : 

 Viperinas: 



Vipera elegans s. Da- 

 boia russellii 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Vipera berus s. Pelias 

 berus 



Do 



Crotalinoe : 



Ancistrodon contortrix 



Do 



Ancistrodon piscivorus 



Do 



Lachesis flavoviridis . . 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Do 



Lachesis lanceolatus . . 

 Lachesis gramineus . . 

 Lachesis neuwiedii . . 



Lachesis mutus 



Crotalus adamanteus . 



Do 



Do 



Do 



Do 



Animal experi- 

 mented upon. 



Rabbit . . 



... do. . 

 ... do. . 

 Guinea-pig 

 ... do. . 

 ... do. . 

 Pigeon . 

 Fowl . . . 

 Monkey 

 Rabbit . , 



Guinea-pig 



Guinea-pig 

 ... do. . 

 Rabbit. . 

 ... do. . 

 ... do. . 

 Guinea-pig 

 Mouse . 

 ... do. . 

 Guinea-pig 

 Rabbit . . 

 Pigeon 12 . 

 Chicken 12 

 Dog 12 . . . 

 Rat 12 . . . 

 Cat 12 



Frog 12 . . . 

 Guinea-pig 

 Rabbit . 

 Guinea-pig 

 ... do. 

 Rabbit . 

 ... do. 

 ... do. 

 Guinea-pig 

 . . . do. . . . 



Nature of 

 injection. 



Intravenous . . 



do 



do 



Intraperitoneal 



do 



do 



Subcutaneous . 



Intravascular . 



Intraperitoneal 



do 



Subcutaneous . 

 do 



Subcutaneous. 



do. . . . 



do 



do 



do 



do 



do 



do 



do 



do 



Intraperitoneal 

 Intravenous . . 

 Subcutaneous. 

 Intraperitoneal 

 Intracerebral . 



Amount of venom 

 administered. 



o.oooi to 0.000075 



0.00005 



0.003 



0.0002 



0.0015 



0.00025 



0.0006 



0.003 



o.ooi to 0.003 



0.004 



0.0006 



0.0225 



O.OOI to 0.0012 



0.0025 



o.oi to O.OII 

 O.OI 



0.02 



0.03 to 0.0005 

 0.0018 to 0.0004 

 0.003 to 0.0005 

 0.003 to 0.0005 



0.006 to O.OOI 



0.03 to 0.0005 



0.06 to O.OOI 



0.18 to 0.003 

 0.18 to 0.003 



0.03 



0.002 



0.03 

 0.03 



0.0004 

 0.0002 



0.005 



0.002 

 0.000125 



Authority. 



Lamb. 



Do. 

 EUiot. 

 Lamb. 

 Calmette.8 

 Noguchi. 

 Lamb. 

 EUiot.7 

 Lamb. 

 Calmette. 



D0.8 



Do.» 

 Noguchi. 

 Do. 



Ishizaka. 

 Calmette. 10 

 Ishizaka. 11 

 Kitashima 



Do. 



Do. 



Do. 



Do. 



Do. 



Do. 



Do. 



Do. 

 Calmette.13 

 Lamb. 

 Cabnette.'s 



Do.»3 

 Noguchi. 



Do. 



Do. 



Flexner and No- 

 guchi. 



1 0.0002 per 600 to 700 grams, another estimate 



of Calmette. 

 ^ 0.000003 per 25 grams. 

 3 0.003 per 600 to 700 grams. 

 ■* 0.0006 per 600 to 700 grams. 

 ^ Proc. Roy. Soc, 1904, 108. 

 6 O.OOI per 600 to 700 grams. 

 7 Elliot. An account of some researches into the 



nature and action of snake venom. Brit. Med. 



Jour., 1900, I, 309, 1146; II, 217. 



s 0.004 per 600 to 700 grams. 



9 0.015 per 600 to 700 grams. 

 10 0.007 PS"" ^°° to 700 grams, 

 n 0.0003 per 13 to 18 grams. 



12 The minimal lethal doses for these animals 



were given in relative values compared to that 

 for the mouse, but the writer reproduced them 

 in grams in order to enable them to be com- 

 pared with the results of the others. 



13 0.02 per 600 to 700 grams. 



venoms, is striking. Then one will quickly notice that viperine as well as 

 crotaline venoms are less fatal than those of the colubrines. The venom of 

 Daboia russellii is, however, an exception to this general rule. Another 

 interesting relation between the action of the colubrine venom and that of the 

 viperine or crotaline venoms is seen in the high resistance offered by Mus 

 against the latter set of venoms. I have often seen instances where the com- 

 mon domestic white rats withstood the intraperitoneal injection of the venoms 

 of Crotalus adamanteus or Ancistrodon piscivorus in a dose of about o.oi gm. 

 This refractory characteristic of white rats was first noticed in Copenhagen, 

 where I tried to find out the minimum lethal dose for that particular animal. 

 Previous to that time I never had any reason to suspect such resistance in 



