OIL-WATER PARTITION EFFECTS 



107 



ation of only 1.8 fold. Similarly in Table xx the concen- 

 trations of the different narcotic substances in water 

 which produce a given degree of narcosis show a 7000 

 fold variation. But the corresponding equilibrium con- 

 centrations in oil show a variation of only 2.5 fold. It is 



TABLE XIX 



THECONCENTRATIONSIN AIR OF VARIOUS NARCOTICS 

 REQUIRED TO PRODUCE A GIVEN DEGREE OF NARCOSIS 

 IN MICE, AND THE CORRESPONDING EQUILIBRIUM 

 CONCENTRATIONS OF THE NARCOTICS IN OLIVE-OIL 



thus clear that there is a very close correspondence be- 

 tween the production of a given degree of narcosis, and 

 the production of a standard concentration of molecules 

 in a lipoid phase. The detailed chemical structure of the 

 molecules does not appear to be of any importance. It 

 is the features of the molecules which determine their 



