CONTENTS 



Preface v 



I. The Cell as a Physico-Chemical Unit 



Introduction i 



Cytochemical aspects 2 



Cytoplasmic gels 4 



Chromosome and gene structure 7 



Physico-chemical aspects 11 



Defence mechanisms 20 



Self-reproducing bodies 22 



Integration 23 



References 24 



II. Possible Actions of Drugs on Surfaces 



Ionic interactions 25 



Dipole interactions and complex formation 32 



Specificity in surface reactions 34 



Mechanism of lysis 36 



The action of oestrogens on monolayers 37 



The effect of micelle formation 39 



Long-range forces 43 



References 45 



III, Membrane Permeability and Drug Action 



Introduction 46 



Membrane permeability and drug structure 48 



Problems of the access of drugs to organs 63 



Examples of the permeability factor in drug action .... 66 



References 73 



IV. Enzymes and Drug Action 



Functions of enzymes 74 



Possible functions of drugs in relation to enzymes .... 75 

 Problems in the analysis of the action of drugs on enzymes . 78 

 The action of drugs on respiration and glycolysis in muscle . 82 

 The action of various enzyme poisons on different physiologi- 

 cal processes 85 



Classification of drugs according to their physiological effect 87 



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