increases approximately 30 fold (from a normal of 6 to 180 mg). With 

 additional iron load, there is an increase in the parenchymal iron granules 

 which closely parallels the increase in the insoluble fraction. 



Thèse studies show that with the administration of certain iron com- 

 pounds to rabbits, significant quantities of iron are présent in the liver 

 which the histochemical method fails to disclose. On the other hand, 

 according to the compound administered, insoluble iron granules may be 

 deposited in the Kuppfer cells, parenchymal cells or both; the biochemical 

 method does not distinguish between insoluble iron from thèse sources. 



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