I 



I 



FURTHER STUDIES ON THE LOCALISATION 

 OF RENIN IN THE KIDNEY 



J. BING and J. KAZIMIERCZAK 



As the chemical structure of renin is unknown, the spécifie histochemi- 

 cal method for renin localisation in the kidney cannot be employed. 

 Our studies are based on détermination in rats of the pressor response 

 to intravenous injection of extracts of fragments of the periglomerular 

 circumferences of the outermost layer of glomenili. The results showed 

 that renin is located in macula densa or (and) in other cells lying around 

 the vas afferens, but so far it cannot be said exactly in which of the 

 perivascular cells. Nor has it been possible to give the final answer to 

 the question about the renin content of the vasa afferentia, as the small 

 amounts found in some of the extracts of thèse vessels may be due to 

 insufficiency of the removal of the adjacent cells from the vasa afferen- 

 tia. 



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