4. In the course of studying the ferments of the regenerating con- 

 nective tissue the activization of non-specific esterases in fibroblast 

 protoplasm was demonstrated in the phase of the most intensive formation 

 of procollagen and in the phase of the formation of the définitive col- 

 lagen bundles. 



5. It has been noted that collagen as well as elastic fibres posses 

 différent chemical character in différent organs. 



6. The amount of collagen albumens in the cernent substance of col- 

 lagen bundles increases with âge. 



7. The regular âge chemical changes of the collagen and elastic fibres 

 hâve been observed. 



8. The collagen fibres suffered the cycle of regular chemical changes 

 in the process of scar formation. The most essential manifestation of 

 thèse changes lies in the facts that the solubility of collagen gradually 

 falls, the accessibility and ability to chemical reaction of différent chemi- 

 cal groups of albumen and mucopolysaccharides of collagen fibres grad- 

 ually decrease. 



9. While healing the main tendency in the development of collagen 

 structures is the substitution of stronger hydrogen and probably covalent 

 bonds for water and some sait links of some chemical components of 

 fibres. The possibility of transforming such a polyphasé and polycom- 

 ponent system as a young collagen fibre into a giant, complex molécule, 

 (the fibre in the scar) is being examined. We are examining the relations 

 between thèse changes of paraplastic structures on the one hand and the 

 graduai fall of metabolism on the other hand. 



10. We hâve already received some data on the possibility of the re- 

 verse development of some abovementioned changes while transplanting 

 the human slcin on the allantochorion of chiclc embryo. 



- 168 



