THE EVOLUTION 



OF THE PROTEIN-POLYSACCHARIDE 



COMPOSITION OF CARDIAC CONNECTIVE 



TISSUE IN THE DEVELOPMENT 



OF RHEUMATIC PROCESS 



G. V. ORLOVSKAYA 



TTie State Institute of Rheumatism 

 of the Ministry of Health of the RSFSR, Moscow 



The principal indices of the protein and polysaccharide composition of the 

 normal connective tissue of cardiac valves and changed one during the 

 development of rheumatic process were studied. The investigations were 

 performed on the basis of the parallel hystochemical and biochemical 

 analysis. Obtained data enabled to establish the composition of foci of 

 pathological changes, determined as mucoid swelling, fibrinoid (fibrinoid 

 swelling), fibrinoid necrosis, hyalinosis, sclerosis. The regularities of 

 changes give ample basis to consider the referred types of pathological 

 connective tissue as différent stages of one and the same process of 

 progressing disorganization of collagen fibers and the ground substance 

 with the involvement of plasma components. 



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