GLYCOGEN IN THE RETINA 

 T. KUWABARA,and D. G. COGAN 



Our finding that glycolytic dehydrogenases were concentrated in Mûller's 

 fibers has prompted a study of glycogen distribution in the retina. This 

 has been the subject of controversy in the past literature. 



By controlled fixation procédures and periodic acid Schiff reactions we 

 found the highest concentration of glycogen in Mviller's fibers. The amount 

 varied with différent species but approximately paralleled the activity of 

 the glycolytic oxidative enzymes. In retinas damaged by lAA or disease 

 the glycogen and the glycolytic enzymes were found to be proportionately 



. increased. 



■ Incubation of retinas in appropriate média resulted in distinct synthesis 

 of glycogen in vitro by Mûller's fibers and probably by other retinal cells. 

 This again was greater iri retinas with pathologie gliosis. 



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