HISTOCHEMICAL CHANGES IN DIFFERENT ELEMENTS 



OF TISSUE UNDER THE PARTIAL REMOVAL AND CHRONIC 



IRRITATION IN THE CORTEX OF THE LARGE 



CEREBRAL HEMISPHERES 



P. ELISEEV 



Moscow, U.S.S.R. 



Under the partial removal and chronic irritation of the cortex of cérébral 

 hémisphères the foUowing changes can be observed in histochemistry of 

 the nervous cells in the cortex of the large cérébral hémisphères. 



During ten days after the removal and irritation of the cortex glycogen 

 can be found, while under the normal condition there is no glycogen at 

 ail. The maximal accumulation of glycogen can be observed in three or 

 five day after the opération, on the first day it can be found around the 

 vessels and in the interstitial substance, but in three or five days it can 

 be found as irregular granules in the nervous and glia-cells. When irrita- 

 ting the cortex glycogen appears in larger doses than under decortication. 

 The quantity of amino acids such as: tryptophan, terosin and histidin is 

 increasing under the partial decortication and irritation especially on the 

 fifth day after the opération. 



In case of removal and irritation of the cortex the division of nervous 

 cells by mitoses can be observed. 



The amout of citochromoxydase in blood and bone marrow diminishes 

 and the quantity of hemoglobin in erythrocytes diminishes as well. 



Under decortication there is a diminution in the quantity of PHK 

 (RNK) in the centre of aseptic inflammation in the cells of connective 

 tissue and under irritation of the cortex in the large cérébral hémisphères 

 the quantity of PHK (RNK) increases. In citoplasm of the neutrophile 

 leucocytes which are being removed into the centre of inflammation PAS 

 positive granules of différent size can be found. 



Thèse granules represent glycogen which is being freed in connection 

 with spécial graininess and is being detached in the water of granules. 



Approaching a heterogeneous body the quantity of leucocytes con- 

 taining glycogen as well as the quantity of glycogen in citoplasm in 

 increasing. 



When the leucocytes are destroyed glicogen is found in the interstitial 

 substance. 



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