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AN HISTOCHEMICAL COMPARISON 



OF ENZYMATIC CHANGES 



IN RATS MADE HYPERTENSIVE BY GOLDBLATT TECHNIQUE 



AND X-RAY EXPOSURE 



R. MCKELVEY 



Department of Anatomy, Ejnory University, Atlanta 22, Georgia, U.S. A. 



The enzymatic changes in varions tissues of rats made hypertensive with 

 the Goldblatt technique were compared with hypertension induced by one 

 1,200 r exposure to X-rays localized upon both kidneys. Qualitative and 

 s ami -quantitative changes were noted in the distribution of: succinic dehy- 

 drogenase, cytochrome oxidase, alkaline phosphatase, adenosine mono- 

 phosphatase (AMP), adenosine triphosphatase (ATP), glucose-1-phospha- 

 tase, glucose-6-phosphatase, and thiamine pyrophosphatase. Staining for 

 total lipids and phospholipids was also done. Change in coUagen and 

 elastic fiber distribution was also determined. The tissues examined were: 

 kidney, adrenal, liver, spleen, heart, abdominal aorta and rénal artery. 



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