66 



ROLAND FISCHER 



Surgical sympathectomy (Harrer and Urban, 1953) or chemical (Dibenamine) 

 (Walther-Biiel, 1949) adrenergic blockage also produce psychotic experiences in 

 certain subjects, possessing high epinephrine and nor-epinephrine (Xickerson 

 et al., 1953) levels 5 to which they apparently are not adapted. 



Hence, it appears that drugs which exhibit their central and/ or peripheral 

 adrenergic blocking activity in smaller doses than e.g. Dibenamine, and simul- 

 taneously display a high affinity for (wool) protein, are able to cause hallucina- 

 tions in very small doses. 



Ill 



Speculations Related to Chemical Structure and Biological Activity 



In examining the chemical structure of some of the compounds displaying 

 increasing affinity to wool, let us consider one aspect. 



NH, CH 3 



(II.. 



NH 



C'H, 



H,CCH 



CH 2 



CH 3 OCH 3 



OCH 3 



Mescaline 

 Mol. \w: 211-6 



Methedrine 

 Mol. w.: 149-1 



H 5 C 2 



C,H 5 j 



CH 3 



LAE 

 Mol. w.:295 



N 



CH;CO 



X I * 



!CH 



1 1 

 1 



/ CH 2 



T 



CH 3 



LSD 

 Mol. w. 323 



5 Only about 20 per cent of hypertensive patients react to 0.5 gm. Dibenamine with 

 a model psychosis (Walther-Biiel, 1949). 



