106 MARTIN G. LARRABEE AND PAUL HOROWICZ 



lations, it may be suggested that metabolism of endogenous substrates during 

 lack of glucose might produce irreversible changes, not only directly by remov- 

 ing essential materials as proposed above, but also secondarily by the formation 

 of toxic products. Such products might include ammonia, for example, or the 

 increased intracellular pH resulting both from production of ammonia and 

 from decreased formation of lactic acid. 



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