248 



INFLUENCE OF TEMPERATURE ON BIOLOGICAL SYSTEMS 



shows that injections of 5 cc of water per 100-gram body weight increased 

 asphyxial survival 24%, a fact which has been noted in many experi- 

 ments but upon which no comments have been made until now. Litter- 



Recovery 



Fig. 6. Effects in neonatal guinea pigs of intraperitoneal ATP upon recovery from 

 sublethal exposures to 95% No + 5% CO2. Time to reach four stages of recovery 

 (first breath, first attempt to right, completion of righting reflex and crawl) graphed as 

 percentages of time reciuired by littei'mate controls. Results of single experiments 

 indicated by positions of short horizontal lines on thin verticle lines. Means of ATP 

 animals connected by broken line. As shown by lines indicating three standard errors 

 of the means (3 SE), the results are highly significant. Data from Miller, Miller 

 and Farrar, 1950. 



Table 8. Effects of combining hypothermia, nembutal and hydrogen peroxide 



Control — Normothermic 

 Control — Normothermic + H>0 

 Hypothermic + peroxide 

 Hypothermic + nembutal + peroxide 



PERCENT OF 

 CONTROL T.O.D. 



100% 

 124% 

 329% 

 543% 



PERCENT OF 



H2O 



CONTROL T.O.D. 



100% 

 265% 

 437% 



PERCENT OF 



HYPOTHERMIC 



+ PEROXIDE 



T.O.D. 



100% 

 162% 



mates cooled to 20° and injected with peroxide had survival times increased 

 to 329% of that of the uninjected control, 265% of that of the water- 

 injected control. The fourth member of each litter was cooled and received 

 Nembutal as well as peroxide. The mean survival times of these were 

 543% of the uninjected control, 437% of the water-injected control, and 

 162% of the animals who were cooled and given peroxide. The fifth mem- 



