V. J. HORGAN AND J. ST. L. PHILPOT 



anti-radiation effect should be shown by pantothenic acid analogues such 

 as pantoyltauryl-p-anisidide, which according to Klein and Lipmann^ 

 suppresses steroid and fatty acid synthesis in liver slices by blocking 

 acetylation. • 



SUMMARY 



(7) Alkaline cuprous-catalysed leuco-brilliant cresyl blue is oxidized by 

 ;z-butanol extracts of lethally X-irradiated mice significantly more than by 

 control extracts, the mean ionic yield being about 80. 



(2) There is some evidence that part of the oxidizing material is less reactive 

 than the y. unsaturated hydroperoxides resulting from the autoxidation of 

 unsaturated lipides. 



(3) Similar behaviour is shown by autoxidized isoprene. 



(4) It is suggested that the precursor of the oxidizing material in mouse 

 extracts may be squalene and its metabolic neighbours. 



REFERENCES 



1 HoRGAN, V. J. and Philpot, J. St. L. Brit. J. Radiol. 1954, 27 63. 



2 SoBEL, H. and Marmorston, J. Mature, Lond. 1954, 174 553. 



3 Holland, J. L. and Hughes, H. J. Chem. Soc. 1949, 492. 



* Langdon, R. G. and Bloch, K. J. Biol. Chem. 1953, 200 129. 



^ GuNSALUs, I. C. Symposium on Mechanisms of Enzyme Action, p. 545. Baltimore, 



Johns Hopkins Press, 1953. 

 6 Klein, H. P. and Lipmann, F. J. Biol. Chem. 1953, 203 101. 



29 



