THE HUMAN RESPONSE TO A SINGLE DOSE OF X-RAYS — THE LATENT PERIOD 



est probable que ce sont les actions metaboliques de ces amines qui sont responsables 

 de ces effets therapeutiques. 



Le mal des rayons est un syndrome generalise, temoin de troubles a distance 

 provoques en dehors du foyer irradie. Notre ignorance de la pathogenic de ces 

 troubles ne permet pas d'etudier avec plus de precision Taction de la cysteamine 

 dans cette affection. 



Le fait que cette substance intervient en hatant la disparition des symptomes et 

 que son action ne se marque qu'apres 24 ou 48 heures nous fait penser que I'effet 



Tableau II 



Te'moin 1 - Becapfan • ^ - H C L 



^ • 2- Benzedrine •S-VftB^ "\ 

 3 Benadryl •5'-HCl/5e ^ 



3-39 



A norexie 



S1-65. 



S-32 



H 



H 



2Z-H-H- 



2f-¥5 



53-75 



Nausees 



t= 



77-87 



28-60 



21-f7 ^ 

 30-50 



I ^'-'^ I 



Vomissemenf 



25-61 



77-97 . 



11-37 



H-0 -70 



y- 



50-72 



¥¥-70 



75-31 



Asfhenie 



0-22 



15- ¥7 



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10 



20 30 W SO 60 10 80 90 100% 



therapeutique (comme I'effet protecteur) serait difficilement mis en evidence par les 

 tests decrits par Court-Brown. 



W. M. Court Brown : In answer to Herve's claims for the efficacy of [i-mercap- 

 toethylamine in the treatment of radiation sickness the following points were made : 

 (7) The reported observations in the development of radiation sickness following a 

 single dose of X-rays have been made because of our lack of knowledge of the effects 

 of a single acute exposure such as may occur in future industrial accidents or during 

 the explosion of nuclear weapons. The condition described as radiation sickness 

 in clinical radiotherapy is not considered to be a serious problem. [2) From previous 

 experience of attempts to assess the value of therapeutic agents on patients being 

 treated in a routine hospital radiotherapy department it is extremely difficult to 

 obtain results which are amenable to subsequent statistical analysis. 



234 



