LABORATORY STUDIES AND CLINICAL TRIALS OF CHEMICAL RADIO-SENSITIZERS 



certain. With regard to the case shown in Figure 4 and treated by X-ray 

 therapy combined with intravenous compound, the graphical presentation 

 indicates a substantial prolongation of life and also of useful life as a result 

 of the treatment ; this conclusion supports the clinical findings in the case 

 of this patient throughout the course of his illness. 



Other compounds 



With regard to the investigations of 2-ethylenimino-l : 4-naphthoquinone 

 both in animal experiments and clinical trials (see page 171), the low solu- 

 bility of this compound presents considerable difficulty and it appears to be 

 desirable to attempt the difficult problem of preparing the corresponding 

 phosphorylated compound, 2-ethylenimino-l : 4-naphthohydroquinone di- 

 phosphate. It is of interest that a focal reaction in the region of the tumour 

 was observed several times in a patient with advanced carcinoma of 



No. 38. A Sm (72jns) X +il/8 



Ca. bronchus R.U.L. Mediastinal glands -inoperable 

 Performance si a I us Limiled mobility rt i^ocal cord 



100 



-12 -10 -8 -6 



Weight lb. f 96 



Tired 

 easily 



-2 



T10-12-S3 

 X+zVS 

 M.T.D. 1S00r 

 in 8 days 



/7« fSI 



8 70 12 n 16 18 ^^ -months 



D 



Pain in rt. side 

 chest and shoulder 

 becoming severe 



177 176 Steady loss 



of iv eight 



Estimated prolongation of life 12 months 

 Figure 4. 



the floor of the mouth after intravenous, injection of about lOmg of 2- 

 ethylenimino-1 : 4-naphthoquinone in 170 ml of normal saline. It is 

 suggested that further study of this compound and related compounds is 

 desirable. 



REFERENCES 



' Mitchell, J. S. Brit. J. Cancer, 1953, 7 313 ; Acta radio/. Stockh. Supp. 116 341. 



2 Mitchell, J. S. and Simon-Reuss I. Nature, Land. 1947, 160 98. 



3 Mitchell, J. S. Brit. J. Cancer, 1948, 2 351. 

 Experientia, 1949, 5 293. 



Ann. Rep. Brit. Emp. Cancer Campaign, 1949, 27 214. 

 ibid, 1950, 28 213. 

 ibid, 1951, 29 192. 

 ibid, 1952, 30 238. 



and Simon-Reuss, I. Brit. J. Cancer, 1952, 6 305. 



188 



* Mitchell, J. S. 

 5 Mitchell, J. S. 

 " Mitchell, J. S. 

 ' Mitchell, J. S. 

 ^ Mitchell, J. S. 

 ^ Mitchell, J. S. 



