110 NEUTRON EFFECTS ON ANIMALS 



the abrupt increase in gamma globulin levels between the fourth and tenth 

 days following irradiation is coincident with, resumption of lymphocyte 

 production. It may also be pointed out that the subsequent parallel 

 fluctuations in gamma globulin concentration and total plasma protein 

 concentration maj^ reasonably be the result of fluctuations in hormonal 

 stimulation of lymphocyte dissolution, for plasma protein depletion is in 

 effect similar to hemorrhage, one of the known stimuli of the pituitary- 

 adrenal cortical mechanism. 



SUMMARY 



Parallel electrophoretic analyses have been made on the plasma and 

 serum of three chickens given a single dose of 169 n, and of two non- 

 irradiated chickens. 



An anomalous relationship was found between the protein concentrations 

 of the plasmas and the corresponding sera. 



The single dose of 169 n was followed on the fourth day by a reduction in 

 concentration of all the plasma proteins, and during the four subsequent 

 months by parallel fluctuations in the concentrations of gamma globulin 

 and total' plasma protein. 



REFERENCES 



(1) TisELius, A., Trans. Faraday Soc, 33, 524 (1937). 



(2) Enns, T., Terrill, H. M., and Garner, J. M., Jr., Chapter 3. 



(3) Genest, p., /. Vet. Med. Assoc, 108, 239 (1946). 



(4) LoNGSWORTH, L. G., /. A7n. Chem. Soc, 61, 529 (1939). 



(5) SvENSSON, H., Kolloid-Z., 87, 181 (1939). 



(6) Sanders, E., Huddleson, I. F., and Schaible, P. J., J. Biol. Chem., 155, 469 



(1944). 



(7) Deutsch, H. F., and Goodloe, M. B., J. Biol. Chem., 161, 1 (1945). 



(8) Krejci, L. E., Leitch, J. L., and Sweeny, L., Chapter 12. 



(9) White, A., and Dougherty, T. F., Ann. N. Y. Acad. Sci., 46, 859 ( 1946). 

 (10) Ross, M. H., AND Ely, J. O., Chapter 18. 



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