PETER ILBERY 



prolonged survival without signs of secondary disease whereas the use of 

 adult haemopoietic homografts invariably results in the syndromes qualified 

 by the degree of genetic divergence of host and donor. 



Although foetal donor heterograft cells gave enhanced survival compared 

 with adult cells, nine out of ten DBA mice given adult haemopoietic tissue 

 and four out of nine DBA mice given 'null' haemopoietic tissue were dead 

 before 30 days when the 30-day survival period was the criterion ; by the end 

 of the six-week post-irradiation period and heterografting, nine out of 

 nine CBA mice given adult haemopoietic tissue and six out of fourteen CBA 

 mice given 'null' haemopoietic tissue were dead i.e., those given 'null' 

 cells were alive. 



Although a capacity for enhanced survival using foetal donor material in 

 heterografting is shown it does not prevent the occurrence of secondary 

 radiation disease in those surviving longer than six weeks which can be 

 obtained with homografting with ' null ' material. 



REFERENCES 



iIlbery, p. L. T., Roller, P. C. and Loutit, J. F. /. nat. Cancer Inst. 20 (1958) 1051 

 2 Barnes, D. W. H., Ilbery, P. L. T. and Loutit, J. F. Nature, Lond. 181 (1958) 488 

 ^BiLLiNGHAM, R. E. and Brent, L. Transplantation Bull. 4 (1957) 67 



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