l.XPr.RIMFA'TS IX HOMOGRAFT SURVIVAL 



Dr. George: I .slioukl like lo ask if you did any autopsies (jn ihc animals uliicli 

 died ? Did you find any cause of death ? 



Mr. Kent: We followed quite a few of the animals with leukocyte counts on alternate 

 days before they died, and marked depression of the leukocyte count is the only real 

 observation I have to make on the cause of death. 



Dr. Pearce: I should be interested to know whether you consider it to be worth 

 while irradiating just the ears of the rabbits so transplanted to see whether there 

 would be any effect on the local tissues that could be included in the possible effect 

 of the graft ? 



Mr. Kent: I should be interested to do this. Dr. Pearce. but I doubt whether it 

 would have any effect on the prolongation of the homograft. 



Dr. Clarke: Why is the rabbit used in this work? The genetic variability is 

 obviously an obstacle in the interpretation of experiments of this kind. If you use 

 inbred lines of rats, or better still, mice, then the genetic variability can at least be 

 minimized to some extent. 



Mr. Kent: I think that the choice of animal is a very vexed question because one 

 always has in mind the clinical applications of these things in the long run, and I 

 think that the choice of inbred animals is obviously going to lead to more success in 

 the experiments. 



Mr. Jackson : Is the black-eared rabtit a Himalayan ? 



Mr. Kent: Not so far as I know. 



Mr. Jackson : If it was, it would be very interesting to see the change in the expression 

 of the gene. I think it should be checked to see whether it is a Himalayan rabbit. 



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