J. M. GARVAN, E. P. GEORGE, F. A. ROCKE AND S. VINCE 



the earlier transfusion, i.e., before five clays, there was, on the average, a 

 definite post-transfusion rise which could be distinguished from the slow rise 

 experienced with the later single transfusion. 



There was evidence that a decrease in specific curie dosage lengthens the 

 time taken to reach the leukocyte count minimum, and that for dose levels 

 below 2 mC/kg this leukopenia is not as severe as for higher dose levels. 



Figures 1, 2 and 3 show the total leukocyte count for rabbits receiving 



10 20 30 40 



Days after dosing with^^^Au 



Figure 1. Total leukocyte count for 8 rabbits receiving 

 0-8 to 1-8 mC/kg dosage of ^^^Au. including 4 rabbits 

 receiving single bone marrow transfusions at 7 days and 



4 controls 



specific curie doses in the ranges 0-8 to 1-8 mC/kg, 2-1 to 3-0 mC/kg and 

 3-0 to 9-4 mC/kg. Survivors, non-survivors, controls and treated rabbits 

 are lumped together except in Figure 2 where those receiving transfusions 

 before five days are represented by a separate graph. 



In general for rabbits receiving specific doses of 2 • 5 and 3-0 mC/kg, there 



10 20 30 AO 



Days after dosing with ^^^Au 



Figure 2. Total leukocyte count for 3 1 rabbits receixing 2 ■ 1 

 to 3-0 mC/kg dosage of i**Au — full line represents 19 

 rabbits, including 6 receiving single bone-marrow trans- 

 fusions at 7 or 8 days, and 13 controls — broken line 

 represents 12 rabbits receiving double transfusions at 4 to 5 

 days, and at 7 to 8 days 



was a steady fall in haemoglobin concentration after dosing, from a value of 

 the order of 15 g per 100 ml. to a value of the order of 10 g per 100 ml. at 

 about 18 days. This was followed by a very slow rise. As yet there are in- 

 sufficient data to state definitely whether transfusion of bone marrow has 

 any effect on haemogloljin concentration, or whether anaemia has been a 

 significant factor in radiation deaths which have occurred. 



63 



